Triethyl orthoformate

Modify Date: 2024-01-01 20:16:42

Triethyl orthoformate Structure
Triethyl orthoformate structure
Common Name Triethyl orthoformate
CAS Number 122-51-0 Molecular Weight 148.200
Density 0.9±0.1 g/cm3 Boiling Point 142.5±0.0 °C at 760 mmHg
Molecular Formula C7H16O3 Melting Point −76 °C(lit.)
MSDS Chinese USA Flash Point 30.0±0.0 °C
Symbol GHS02
GHS02
Signal Word Warning

 Names

Name Triethyl orthoformate
Synonym More Synonyms

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 142.5±0.0 °C at 760 mmHg
Melting Point −76 °C(lit.)
Molecular Formula C7H16O3
Molecular Weight 148.200
Flash Point 30.0±0.0 °C
Exact Mass 148.109940
PSA 27.69000
LogP 2.14
Vapour density 5.11 (vs air)
Vapour Pressure 7.0±0.2 mmHg at 25°C
Index of Refraction 1.400
Water Solubility 1.35 g/L

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RM6475000
CHEMICAL NAME :
Orthoformic acid, triethyl ester
CAS REGISTRY NUMBER :
122-51-0
BEILSTEIN REFERENCE NO. :
0605384
LAST UPDATED :
199806
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C7-H16-O3
MOLECULAR WEIGHT :
148.23
WISWESSER LINE NOTATION :
2OYO2&O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,352,1986
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,352,1986 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7060 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4000 ppm/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>10 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,917,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84005 No. of Facilities: 5 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 20 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84005 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1582 (estimated) No. of Female Employees: 323 (estimated)

 Safety Information

Symbol GHS02
GHS02
Signal Word Warning
Hazard Statements H226
Precautionary Statements P210-P403 + P235
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi:Irritant
Risk Phrases R10;R36/38
Safety Phrases S16-S26-S37/39
RIDADR UN 2524 3/PG 3
WGK Germany 1
RTECS RM6475000
Packaging Group III
Hazard Class 3
HS Code 2915130000

 Synthetic Route

 Customs

HS Code 2909199090
Summary 2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

 Articles5

More Articles
Triethyl orthoformate mediated a novel crosslinking method for the preparation of hydrogels for tissue engineering applications: characterization and in vitro cytocompatibility analysis.

Mater. Sci. Eng. C. Mater. Biol. Appl. 56 , 154-64, (2015)

This paper describes the development of a new crosslinking method for the synthesis of novel hydrogel films from chitosan and PVA for potential use in various biomedical applications. These hydrogel m...

Geometry and Spin Change at the Heart of a Cobalt(II) Complex: A Special Case of Solvatomorphism.

Chemistry 21 , 9474-81, (2015)

Structural analysis and spectroscopic methods revealed a special case of solvatomorphism: hydrogen-bonding-induced geometry and spin change within a same N,O-(bis)chelate of cobalt(II). Solid-state st...

An efficient synthesis of achiral and chiral 1,2,4-triazolium salts: bench stable precursors for N-heterocyclic carbenes.

J. Org. Chem. 70(14) , 5725-8, (2005)

[reaction: see text] The promising utility of triazolyl N-heterocyclic carbene catalysts in umpolung aldehyde chemistry requires a straightforward reliable synthesis from readily available materials. ...

 Synonyms

1,1,1-Triethoxymethane
triethoxymethane
EINECS 204-550-4
Ethyl orthoformate
UNII:355LRR361Q
Orthopropionic Acid Triethyl Ester
Orthoformic acid, triethyl ester
4-02-00-00025 (Beilstein Handbook Reference)
ortho-formic acid triethyl ester
(Diethoxymethoxy)ethane
Formylolate
MFCD00009230
1,1,1-Triethoxypropane
ethyl-orthoformate
triethyl ortho formate
Triethyl orthoformate
Orthoformic acid triethyl ester
ETHYL-O-FORMATE
Ethyl orthoformate [UN2524] [Flammable liquid]
1,1',1''-[methanetriyltris(oxy)]triethane
AETHON
ETHONE
triethylorthoformate
TEOF
Triethoxmethane
Ethyl Orthopropionate
Methane, triethoxy-
triethoxy-methan
Triethyl Orthopropionate
Propane, 1,1,1-triethoxy-
Ethane, 1,1',1''-[methylidynetris(oxy)]tris-
ortho-formic
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