JW 67
Modify Date: 2025-09-12 19:00:25
JW 67 structure
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Common Name | JW 67 | ||
|---|---|---|---|---|
| CAS Number | 442644-28-2 | Molecular Weight | 394.37700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H18N2O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of JW 67JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17μM[1]. JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth[1]. |
| Name | Trispiro[indole-3,2'-[1,3]dioxane-5',5''-[1,3]dioxane-2'',3'''-in dole]-2,2'''(1H,1'''H)-dione |
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| Description | JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17μM[1]. JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth[1]. |
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| Related Catalog | |
| Target |
IC50: 1.17μM (Wnt signaling)[1] |
| In Vitro | JW67 (1 μM; 24 hours) increases concentration of AXIN2 and decreases the active form of β-catenin[1]. JW67 affects the expression of Wnt target genes and reduces cell growth of colon cancer cell lines[1]. JW67 shows a concentrationdependent reduction in proliferation with a GI50 value of 7.8 μM[1]. Western Blot Analysis[1] Cell Line: SW480 cells Concentration: 1 μM Incubation Time: 24 hours Result: Increased the AXIN2 expression. RT-PCR[1] Cell Line: SW480 cells Concentration: 10 or 25μM Incubation Time: 72 hours Result: Reduced growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S. |
| References |
| Molecular Formula | C21H18N2O6 |
|---|---|
| Molecular Weight | 394.37700 |
| Exact Mass | 394.11600 |
| PSA | 102.10000 |
| LogP | 1.84680 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| RIDADR | UN 2811 6.1 / PGIII |
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