1222998-57-3
1222998-57-3 structure
- Name: JW-7-25-1
- Chemical Name: JW-7-25-1
- CAS Number: 1222998-57-3
- Molecular Formula: C29H23F3N4O2
- Molecular Weight: 516.524
- Create Date: 2020-01-12 14:02:50
- Modify Date: 2025-08-25 12:41:28
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JW-7-25-1 is a potent MELK inhibitor with biochemical IC50 of 5.0 nM, also inhibits PIK3CA, mTOR, GSK3A and CDK7 with CI50 of 5-60 nM; exhibits a broad kinase selectivity profile with an S(35) score of 0.54 at 10 uM.
| Name | JW-7-25-1 |
|---|
| Description | JW-7-25-1 is a potent MELK inhibitor with biochemical IC50 of 5.0 nM, also inhibits PIK3CA, mTOR, GSK3A and CDK7 with CI50 of 5-60 nM; exhibits a broad kinase selectivity profile with an S(35) score of 0.54 at 10 uM. |
|---|---|
| References | References 1. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693. View Related Products by Target MELK |
| Molecular Formula | C29H23F3N4O2 |
|---|---|
| Molecular Weight | 516.524 |