JW 642

Modify Date: 2024-01-10 20:08:13

JW 642 structure	Common Name	JW 642
	CAS Number	1416133-89-5	Molecular Weight	462.385
	Density	1.4±0.1 g/cm3	Boiling Point	432.9±45.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₀F₆N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	215.6±28.7 °C

Use of JW 642

JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.IC50 value: 7.6/14/3.7 nM(mouse/rat/human MAGL) [1]Target: MAGL inhibitorJW 642 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s = 31, 14, and 20.6 μM for mouse, rat, and human brain membranes, respectively).

Name	1,1,1,3,3,3-Hexafluoro-2-propanyl 4-(3-phenoxybenzyl)-1-piperazin ecarboxylate
Synonym	More Synonyms

Description	JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.IC50 value: 7.6/14/3.7 nM(mouse/rat/human MAGL) [1]Target: MAGL inhibitorJW 642 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s = 31, 14, and 20.6 μM for mouse, rat, and human brain membranes, respectively).
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL Research Areas >> Neurological Disease
References	[1]. Chang JW, et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol. 2012 May 25;19(5):579-88.

Density	1.4±0.1 g/cm3
Boiling Point	432.9±45.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₀F₆N₂O₃
Molecular Weight	462.385
Flash Point	215.6±28.7 °C
Exact Mass	462.137817
PSA	42.01000
LogP	6.43
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.511
Storage condition	2-8℃

1,1,1,3,3,3-Hexafluoro-2-propanyl 4-(3-phenoxybenzyl)-1-piperazinecarboxylate

1,1,1,3,3,3-hexafluoroisopropyl cyanoacetate

1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester

JW 642

JW-642

DC Chemicals Limited
China
Product Name: JW 642
Price: $Inquiry/100mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $60/5mg

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JW 642

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