AUTEN-67
Modify Date: 2025-08-24 20:14:38
AUTEN-67 structure
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Common Name | AUTEN-67 | ||
|---|---|---|---|---|
| CAS Number | 1783800-77-0 | Molecular Weight | 474.445 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 689.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C23H14N4O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 370.9±34.3 °C | |
Use of AUTEN-67A small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively; shows no activity for CDC25B , other phosphatase, PTPN1; significantly increases autophagic flux in cell lines and in vivo models, promotes longevity and protects neurons from undergoing stress-induced cell death; also restores nesting behavior in a murine model of Alzheimer disease, without apparent side effects. |
| Name | N-[3-(1H-Benzimidazol-1-yl)-1,4-dioxo-1,4-dihydro-2-naphthalenyl]-4-nitrobenzenesulfonamide |
|---|---|
| Synonym | More Synonyms |
| Description | A small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively; shows no activity for CDC25B , other phosphatase, PTPN1; significantly increases autophagic flux in cell lines and in vivo models, promotes longevity and protects neurons from undergoing stress-induced cell death; also restores nesting behavior in a murine model of Alzheimer disease, without apparent side effects. |
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| References | References 1. Papp D, et al. Autophagy. 2016;12(2):273-86. 2. Billes V, et al. J Huntingtons Dis. 2016 May 7;5(2):133-47. View Related Products by Target Autophagy |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 689.7±65.0 °C at 760 mmHg |
| Molecular Formula | C23H14N4O6S |
| Molecular Weight | 474.445 |
| Flash Point | 370.9±34.3 °C |
| Exact Mass | 474.063416 |
| LogP | 3.68 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.755 |
| InChIKey | FSAINSJUQREKEK-UHFFFAOYSA-N |
| SMILES | O=C1C(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)=C(n2cnc3ccccc32)C(=O)c2ccccc21 |
| MFCD30724098 |
| Benzenesulfonamide, N-[3-(1H-benzimidazol-1-yl)-1,4-dihydro-1,4-dioxo-2-naphthalenyl]-4-nitro- |
| N-[3-(1H-Benzimidazol-1-yl)-1,4-dioxo-1,4-dihydro-2-naphthalenyl]-4-nitrobenzenesulfonamide |