AUTEN-67

Names

[ Name ]:
AUTEN-67

[Synonym ]:
MFCD30724098
Benzenesulfonamide, N-[3-(1H-benzimidazol-1-yl)-1,4-dihydro-1,4-dioxo-2-naphthalenyl]-4-nitro-
N-[3-(1H-Benzimidazol-1-yl)-1,4-dioxo-1,4-dihydro-2-naphthalenyl]-4-nitrobenzenesulfonamide

Biological Activity

[Description]:

A small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively; shows no activity for CDC25B , other phosphatase, PTPN1; significantly increases autophagic flux in cell lines and in vivo models, promotes longevity and protects neurons from undergoing stress-induced cell death; also restores nesting behavior in a murine model of Alzheimer disease, without apparent side effects.

[References]

References 1. Papp D, et al. Autophagy. 2016;12(2):273-86. 2. Billes V, et al. J Huntingtons Dis. 2016 May 7;5(2):133-47. View Related Products by Target Autophagy

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
689.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₁₄N₄O₆S

[ Molecular Weight ]:
474.445

[ Flash Point ]:
370.9±34.3 °C

[ Exact Mass ]:
474.063416

[ LogP ]:
3.68

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.755

Related Compounds

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