302841-89-0
302841-89-0 structure
- Name: Ro 67-4853
- Chemical Name: butyl N-(9H-xanthene-9-carbonyl)carbamate
- CAS Number: 302841-89-0
- Molecular Formula: C19H19NO4
- Molecular Weight: 325.358
- Catalog: Signaling Pathways GPCR/G Protein mGluR
- Create Date: 2017-11-25 18:47:05
- Modify Date: 2025-08-27 12:01:32
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Ro 67-4853 is a positive allosteric modulator (PAM) of mGluR1 (pEC50=7.16 for rmGlu1a receptor). Ro67-4853 exhibits activity at all group I mGlu receptors including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 enhances the potency of L-Glu by interacting with the transmembrane domain (TMD) of the receptor. Ro 67-4853 potentiates sensory synaptic responses to repetitive vibrissa stimulation[1][2][3][4].
| Name | butyl N-(9H-xanthene-9-carbonyl)carbamate |
|---|---|
| Synonyms |
Carbamic acid, N-(9H-xanthen-9-ylcarbonyl)-, butyl ester
Ro67-4853 Butyl (9H-xanthen-9-ylcarbonyl)carbamate |
| Description | Ro 67-4853 is a positive allosteric modulator (PAM) of mGluR1 (pEC50=7.16 for rmGlu1a receptor). Ro67-4853 exhibits activity at all group I mGlu receptors including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 enhances the potency of L-Glu by interacting with the transmembrane domain (TMD) of the receptor. Ro 67-4853 potentiates sensory synaptic responses to repetitive vibrissa stimulation[1][2][3][4]. |
|---|---|
| Related Catalog | |
| Target |
Rat mGluR1a:7.16 (pEC50) |
| In Vitro | Ro67-4853 selectively potentiates responses to the agonist DHPG[2]. Ro 67-4853 (1 µM) shifts the concentration-response curve (CRC) of glutamate approximately 2-fold, 15-fold, and 4.5-fold to the left respectively in BHK cells stably expressing mGluR1a[4]. Ro 67-4853 (1 µM) activates p-ERK1/2 in the absence of agonist with a time course of activation peaking at 5 minutes in BHK cells[4]. Ro 67-4853 (500 nM) potentiates glutamate-induced activation of mGluR1 as assessed by measures of cAMP production. Glutamate increases cAMP accumulation with an EC50 value of 32.08 µM in the absence of Ro 67-4853. The EC50 values for glutamate in the presence of Ro 67-4853 is 2.15 µM. Ro 67-4853 increases basal mGluR1-induced cAMP accumulation and potentiate glutamate-induced cAMP accumulation but have lower potencies at modulating the cAMP response than at regulating ERK1/2 phosphorylation or calcium mobilization[4]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C19H19NO4 |
| Molecular Weight | 325.358 |
| Exact Mass | 325.131409 |
| PSA | 64.63000 |
| LogP | 3.96 |
| Index of Refraction | 1.578 |
| Symbol |
GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H410 |
| Precautionary Statements | P273-P391-P501 |
| RIDADR | UN 3077 9 / PGIII |