1360821-21-1
1360821-21-1 structure
- Name: RO-2468
- Chemical Name: (2S,3R,4S,5R)-N-(4-Carbamoyl-2-methoxyphenyl)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-carboxamide
- CAS Number: 1360821-21-1
- Molecular Formula: C30H30Cl2FN5O4
- Molecular Weight: 614.495
- Catalog: Signaling Pathways Apoptosis MDM-2/p53
- Create Date: 2020-01-16 18:50:55
- Modify Date: 2024-01-09 18:23:56
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A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM; exhibits substantial cellular antiproliferative potency/selectivity and comparse favorably to RO8994; displays tumor regression in tumor models at 10 mg/kg.
| Name | (2S,3R,4S,5R)-N-(4-Carbamoyl-2-methoxyphenyl)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-carboxamide |
|---|---|
| Synonyms |
(2S,3R,4S,5R)-N-(4-Carbamoyl-2-methoxyphenyl)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-carboxamide
Spiro[pyrrolidine-3,3'-[3H]pyrrolo[3,2-c]pyridine]-5-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-1',2'-dihydro-2'-oxo-, (2S,3R,4S,5R)- |
| Description | A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM; exhibits substantial cellular antiproliferative potency/selectivity and comparse favorably to RO8994; displays tumor regression in tumor models at 10 mg/kg. |
|---|---|
| References | References 1. Zhang Z, et al. ACS Med Chem Lett. 2013 Dec 29;5(2):124-7. View Related Products by Target MDM2-p53 |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 770.2±60.0 °C at 760 mmHg |
| Molecular Formula | C30H30Cl2FN5O4 |
| Molecular Weight | 614.495 |
| Flash Point | 419.6±32.9 °C |
| Exact Mass | 613.165894 |
| LogP | 6.17 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.657 |