Fmoc-Leu-OH

Modify Date: 2025-08-21 18:20:07

Fmoc-Leu-OH Structure
Fmoc-Leu-OH structure
 Common Name Fmoc-Leu-OH
CAS Number 35661-60-0 Molecular Weight 353.412
Density 1.2±0.1 g/cm3 Boiling Point 559.8±33.0 °C at 760 mmHg
Molecular Formula C21H23NO4 Melting Point 152-156 °C(lit.)
MSDS Chinese USA Flash Point 292.4±25.4 °C

 Use of Fmoc-Leu-OH


Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].

 Names

Name (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpentanoic acid
Synonym More Synonyms

 Fmoc-Leu-OH Biological Activity

Description Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].
Related Catalog
Target

PPARγ

References

[1]. Rocchi S, et al. A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell. 2001 Oct;8(4):737-47.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 559.8±33.0 °C at 760 mmHg
Melting Point 152-156 °C(lit.)
Molecular Formula C21H23NO4
Molecular Weight 353.412
Flash Point 292.4±25.4 °C
Exact Mass 353.162720
PSA 75.63000
LogP 4.95
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.583
Storage condition 2~8°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2924299090

 Synthetic Route

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles8

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 Synonyms

D-LeuFmoc-OH
Fmoc-Leu-OH
N-((9H-Fluoren-9-ylmethoxy)carbonyl)-L-leucine
EINECS 252-662-7
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-methylpentanoic acid
MFCD00037133
Tocris-0675
FMOC-D-LEU
Fmoc-D-Leu-OH
Fmoc-L-leucine
Fmoc-L-Leu-OH
L-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-leucine
Fmoc-D-leucine-OH
N-Fmoc-D-leucine
D-Fmoc-Leu-OH
N-Fmoc-L-leucine
D-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
Fmoc-D-Leucine
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine
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