Fmoc-leucine-d10

Modify Date: 2024-01-04 10:56:21

Fmoc-leucine-d10 structure	Common Name	Fmoc-leucine-d10
	CAS Number	1190594-22-9	Molecular Weight	363.47
	Density	1.2±0.1 g/cm3	Boiling Point	559.8±33.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₁₃D₁₀NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	292.4±25.4 °C

Use of Fmoc-leucine-d10

Fmoc-leucine-d10 is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].

Name	FMoc-[D10]Leu-OH
Synonym	More Synonyms

Description	Fmoc-leucine-d10 is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Rocchi S, et al. A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell. 2001 Oct;8(4):737-47.

Density	1.2±0.1 g/cm3
Boiling Point	559.8±33.0 °C at 760 mmHg
Molecular Formula	C₂₁H₁₃D₁₀NO₄
Molecular Weight	363.47
Flash Point	292.4±25.4 °C
Exact Mass	363.225464
LogP	4.95
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.583

N-(9-Fluorenylmethoxycarbonyl)-L-leucine-d10

L-Leucine-d10, N-Fmoc

MFCD06658583

L-Leucine-2,3,3,4,5,5,5,5',5',5'-d10, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

Fmoc-Leu-OH-d10

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-(2,3,3,4,5,5,5,5',5',5'-2H10)leucine

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Fmoc-[D10]Leu-OH
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Fmoc-leucine-d10

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