1190594-22-9

1190594-22-9 structure

Name: Fmoc-leucine-d10
Chemical Name: FMoc-[D10]Leu-OH
CAS Number: 1190594-22-9
Molecular Formula: C₂₁H₁₃D₁₀NO₄
Molecular Weight: 363.47
Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
Create Date: 2018-02-14 23:20:45
Modify Date: 2024-01-04 10:56:21
Fmoc-leucine-d10 is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].

Name	FMoc-[D10]Leu-OH
Synonyms	N-(9-Fluorenylmethoxycarbonyl)-L-leucine-d10 L-Leucine-d10, N-Fmoc MFCD06658583 L-Leucine-2,3,3,4,5,5,5,5',5',5'-d10, N-[(9H-fluoren-9-ylmethoxy)carbonyl]- Fmoc-Leu-OH-d10 N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-(2,3,3,4,5,5,5,5',5',5'-2H10)leucine

Description	Fmoc-leucine-d10 is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Rocchi S, et al. A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell. 2001 Oct;8(4):737-47.