[Pyr1] -Apelin 13

Modify Date: 2025-08-22 01:19:38

Use of [Pyr1] -Apelin 13

[Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist.

Name	[Pyr1]-Apelin-13
Synonym	More Synonyms

Description	[Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist.
Related Catalog	Signaling Pathways >> Others >> Others Peptides Research Areas >> Cardiovascular Disease
In Vitro	[Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release under physiological conditions[1].
In Vivo	[Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction[1]. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold compared to SCI animals from the second week post SCI[2].
References	[1]. Serpooshan V, et al. [Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction. Biomaterials. 2015 Jan;37:289-98. [2]. Hajimashhadi Z, et al. Chronic administration of [Pyr1] apelin-13 attenuates neuropathic pain after compression spinal cord injury in rats. Neuropeptides. 2017 Feb;61:15-22.

Fmoc-Gly-OH

CAS#:29022-11-5

Fmoc-Leu-OH

CAS#:35661-60-0

Fmoc-Pro-OH

CAS#:71989-31-6

FMOC-L-Phenylalanine

CAS#:35661-40-6

Fmoc-Met-OH

CAS#:71989-28-1

Detail

Literature: Zhang, Yanyan; Maitra, Rangan; Harris, Danni L.; Dhungana, Suraj; Snyder, Rodney; Runyon, Scott P. Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 11 p. 2992 - 2997

Precursor 7
CAS#:29022-11-5 Fmoc-Gly-OH CAS#:35661-60-0 Fmoc-Leu-OH CAS#:71989-31-6 Fmoc-Pro-OH CAS#:35661-40-6 FMOC-L-Phenylalanine
CAS#:71989-28-1 Fmoc-Met-OH CAS#:116611-64-4 Fmoc-His-OH CAS#:98-79-3 L-Pyroglutamicacid
DownStream 0

PGLU-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE

pQRPRLSHKGPMPF

Deltorphin I

PYR-RPRLSHKGPMPF-OH

GLP-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE

5-Oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine

L-Phenylalanine, 5-oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-

PYR-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE

pyroglutamyl apelin-13

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Price: $120/1mg

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