(Ala13)-Apelin-13 (human, bovine, mouse, rat) acetate salt

Modify Date: 2024-01-05 13:03:57

(Ala13)-Apelin-13 (human, bovine, mouse, rat) acetate salt Structure
(Ala13)-Apelin-13 (human, bovine, mouse, rat) acetate salt structure
Common Name (Ala13)-Apelin-13 (human, bovine, mouse, rat) acetate salt
CAS Number 568565-11-7 Molecular Weight 1474.73000
Density N/A Boiling Point N/A
Molecular Formula C63H107N23O16S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (Ala13)-Apelin-13 (human, bovine, mouse, rat) acetate salt


(Ala13)-Apelin-13 is a potent apelin receptors (APJ) antagonist. (Ala13)-Apelin-13 inhibits gastric motility through vagal cholinergic pathway[1].

 Names

Name h-gln-arg-pro-arg-leu-ser-his-lys-gly-pro-met-pro-ala-oh
Synonym More Synonyms

  Biological Activity

Description (Ala13)-Apelin-13 is a potent apelin receptors (APJ) antagonist. (Ala13)-Apelin-13 inhibits gastric motility through vagal cholinergic pathway[1].
Related Catalog
In Vivo (Ala13)-Apelin-13 (1-300 pmol/60 nl;显微注射到 DVC 中) 以剂量依赖性方式降低大鼠的胃张力和胃动力[1]。 Animal Model: 250-300 g, Sprague-Dawley rats[1] Dosage: 1-300 pmol/60 nl Administration: Microinjected into the DVC (dorsal vagal complex (DVC) Result: Decreased gastric tone and motility in a dose-dependent manner with D50 ≈ 27 pmol for both antrum and corpus.
References

[1]. Bülbül M, et al. Apelin-13 inhibits gastric motility through vagal cholinergic pathway in rats. Am J Physiol Gastrointest Liver Physiol. 2018 Feb 1;314(2):G201-G210.  

 Chemical & Physical Properties

Molecular Formula C63H107N23O16S
Molecular Weight 1474.73000
Exact Mass 1473.80000
PSA 653.27000
LogP 0.87870
Storage condition -20°C

 Synonyms

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GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA
(Ala13)-Apelin-13 (human, bovine, mouse, rat)
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