Fmoc-Leu-OH
Fmoc-Leu-OH structure
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Common Name | Fmoc-Leu-OH | ||
|---|---|---|---|---|
| CAS Number | 35661-60-0 | Molecular Weight | 353.412 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 559.8±33.0 °C at 760 mmHg | |
| Molecular Formula | C21H23NO4 | Melting Point | 152-156 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 292.4±25.4 °C | |
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Aspartate-modified doxorubicin on its N-terminal increases drug accumulation in LAT1-overexpressing tumors.
Cancer Sci. 106 , 747-56, (2015) L-type amino acid transporter 1 (LAT1), overexpressed on the membrane of various tumor cells, is a potential target for tumor-targeting therapy. This study aimed to develop a LAT1-mediated chemotherapeutic agent. We screened doxorubicin modified by seven diff... |
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Ceramide as a mediator of non-alcoholic Fatty liver disease and associated atherosclerosis.
PLoS ONE 10 , e0126910, (2015) Cardiovascular disease (CVD) is a serious comorbidity in nonalcoholic fatty liver disease (NAFLD). Since plasma ceramides are increased in NAFLD and sphingomyelin, a ceramide metabolite, is an independent risk factor for CVD, the role of ceramides in dyslipid... |
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Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model.
Sci. Rep. 4 , 6777, (2014) Amyloid-β (Aβ) is one of the few neuropathological biomarkers associated with transporters of the blood-brain barrier (BBB). Despite the well-characterized clinical indication of decreasing Aβ levels in the cerebrospinal fluid (CSF) during the development of ... |
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Self-assembly of small molecules affords multifunctional supramolecular hydrogels for topically treating simulated uranium wounds.
Chem. Commun. (Camb.) (35) , 4414-6, (2005) Two types of therapeutic agents, which have discrete yet complementary functions, self-assemble into nanofibers in water to formulate a new supramolecular hydrogel as a self-delivery biomaterial to reduce the toxicity of uranyl oxide at the wound sites. |
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Hydrogelation and self-assembly of Fmoc-tripeptides: unexpected influence of sequence on self-assembled fibril structure, and hydrogel modulus and anisotropy.
Langmuir 26(7) , 4990-8, (2010) The self-assembly and hydrogelation properties of two Fmoc-tripeptides [Fmoc = N-(fluorenyl-9-methoxycarbonyl)] are investigated, in borate buffer and other basic solutions. A remarkable difference in self-assembly properties is observed comparing Fmoc-VLK(Bo... |
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Guinea pig ileitis is attenuated by the leumedin N-(fluorenyl-9- methoxycarbonyl)-leucine (NPC 15199).
J. Pharmacol. Exp. Ther. 266(1) , 468-72, (1993) Anti-inflammatory properties have been ascribed to a series of N-(fluorenyl-9-methoxycarbonyl) amino acids called leumedins that inhibit the activity of granulocytes and T-lymphocytes. We evaluated one of these leumedins, N-(fluorenyl-9-methoxycarbonyl) leuci... |
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NPC-15199, a novel anti-inflammatory agent, mobilizes intracellular Ca2+ in bladder female transitional carcinoma (BFTC) cells.
Chin. J. Physiol. 43(1) , 29-33, (2000) This report demonstrates that NPC-15199 [(N-(9-fluorenylmethoxycarbonyl)L-leucine)], a novel anti-inflammatory agent, increases intracellular Ca2+ concentration ([Ca2+]i) in human bladder female transitional cancer (BFTC) cells. Using fura-2 as a Ca2+ probe, ... |
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Effect of NPC-15199 on Ca2+ levels in renal tubular cells.
Chin. J. Physiol. 45(3) , 117-22, (2002) In Madin-Darby canine kidney (MDCK) cells, effect of NPC-15199 on intracellular Ca2+ concentration ([Ca2+]i) was investigated by using fura-2. NPC-15199 (100-1000 microM) caused a rapid and sustained increase of [Ca2+]i in a concentration-dependent manner (EC... |