2-Amino-6-chloropurine

Modify Date: 2024-01-03 10:38:10

2-Amino-6-chloropurine Structure
2-Amino-6-chloropurine structure
Common Name 2-Amino-6-chloropurine
CAS Number 10310-21-1 Molecular Weight 169.57
Density 1.8±0.1 g/cm3 Boiling Point 315.2ºC at 760mmHg
Molecular Formula C5H4ClN5 Melting Point >300 °C(lit.)
MSDS Chinese USA Flash Point 144.4ºC

 Use of 2-Amino-6-chloropurine


6-Chloroguanine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

 Names

Name 6-chloroguanine
Synonym More Synonyms

 2-Amino-6-chloropurine Biological Activity

Description 6-Chloroguanine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Related Catalog
In Vitro 2-Amino-6-chloropurine 是合成核苷酸类似物的前体,具有抗 Epstein-Barr 病毒 (EBV) 和人类疱疹病毒 6 (HHV-6) 的抗病毒活性。11.Qiu, Y.-L., Ksebati, MB, Ptak, RG, et al.(Z)-和 (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine 和-guanine。具有广谱抗病毒活性的新型核苷酸类似物 J.医学。化学 41(1) 10-23 (1998)
References

[1]. Qiu, Y.-L., Ksebati, MB, Ptak, RG, et al.(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleotide analogues with a broad-spectrum antiviral activityJ. Med. Chem.41(1) 10-23 (1998).

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 315.2ºC at 760mmHg
Melting Point >300 °C(lit.)
Molecular Formula C5H4ClN5
Molecular Weight 169.57
Flash Point 144.4ºC
Exact Mass 169.015518
PSA 80.48000
LogP -0.03
Vapour Pressure 1.75E-15mmHg at 25°C
Index of Refraction 1.827
Storage condition Keep Cold
Water Solubility 1.7 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UO7502000
CHEMICAL NAME :
Purine, 2-amino-6-chloro-
CAS REGISTRY NUMBER :
10310-21-1
LAST UPDATED :
199206
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C5-H4-Cl-N5
MOLECULAR WEIGHT :
169.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
20 mg/L/24H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 139,149,1984

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi,Xn
Risk Phrases R20/21/22
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UO7502000
HS Code 2933990090

 Synthetic Route

~68%

2-Amino-6-chloropurine Structure

2-Amino-6-chlor...

CAS#:10310-21-1

Literature: Luo, Lei; Chen, Guorong; Li, Yuanchao Heterocycles, 2008 , vol. 75, # 11 p. 2803 - 2808

~85%

2-Amino-6-chloropurine Structure

2-Amino-6-chlor...

CAS#:10310-21-1

Literature: Hu, Yu Lin; Ge, Qiang; Lu, Ming; Lu, Hong Fei Bulletin of the Chemical Society of Ethiopia, 2010 , vol. 24, # 3 p. 425 - 432

~86%

2-Amino-6-chloropurine Structure

2-Amino-6-chlor...

CAS#:10310-21-1

Literature: Steklov, Mikhail Yu.; Tararov, Vitali I.; Romanov, Georgy A.; Mikhailov, Sergey N. Nucleosides, Nucleotides and Nucleic Acids, 2011 , vol. 30, # 7-8 p. 503 - 511

~%

2-Amino-6-chloropurine Structure

2-Amino-6-chlor...

CAS#:10310-21-1

Literature: Journal of Heterocyclic Chemistry, , vol. 48, # 5 p. 1140 - 1144

~%

2-Amino-6-chloropurine Structure

2-Amino-6-chlor...

CAS#:10310-21-1

Literature: Nucleosides, Nucleotides and Nucleic Acids, , vol. 30, # 7-8 p. 503 - 511

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles14

More Articles
The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors.

Bioorg. Med. Chem. 15 , 3450-6, (2007)

Xanthine oxidase (XO) is a key enzyme which can catalyze xanthine to uric acid causing hyperuricemia in humans. By using the fractionation technique and inhibitory activity assay, an active compound t...

Molecular crowding enhances facilitated diffusion of two human DNA glycosylases.

Nucleic Acids Res. 43 , 4087-97, (2015)

Intracellular space is at a premium due to the high concentrations of biomolecules and is expected to have a fundamental effect on how large macromolecules move in the cell. Here, we report that crowd...

Additive Pummerer reaction of 3,5-O-(di-tert-butyl)silylene-4-thiofuranoid glycal: a high-yield and beta-selective entry to 4'-thioribonucleosides.

J. Org. Chem. 74(6) , 2616-9, (2009)

Upon reacting 3,5-O-(di-tert-butyl)silylene-4-thiofuranoid glycal S-oxide (6) with Ac(2)O/TMSOAc/BF(3) x OEt(2) in CH(2)Cl(2), the additive Pummerer reaction proceeded to furnish the corresponding 1,2...

 Synonyms

2-Amino-6-Chloro-Purin
2-Amino-6-chloropurine
MFCD00075252
EINECS 233-686-7
6-Chloroguanine
9H-Purin-2-amine, 6-chloro-
6-Chloro-3H-purin-2-amine
2-AMINO-6-CHLORO-PURINE
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