2'-C-Methylguanosine

Modify Date: 2025-08-31 18:16:50

2'-C-Methylguanosine structure	Common Name	2'-C-Methylguanosine
	CAS Number	374750-30-8	Molecular Weight	297.27
	Density	2.0±0.1 g/cm3	Boiling Point	733.1±70.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₅N₅O₅	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	397.2±35.7 °C

Use of 2'-C-Methylguanosine

2'-C-Methylguanosine (2'-C-beta-Methylguanosine) is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

Name	2-amino-9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-3H-purin-6-one
Synonym	More Synonyms

Description	2'-C-Methylguanosine (2'-C-beta-Methylguanosine) is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

Density	2.0±0.1 g/cm3
Boiling Point	733.1±70.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₅N₅O₅
Molecular Weight	297.27
Flash Point	397.2±35.7 °C
Exact Mass	297.107330
PSA	159.51000
LogP	0.34
Appearance of Characters	white to beige
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.860
Storage condition	?20°C
Water Solubility	H2O: soluble5mg/mL, clear (warmed)

2'-C-Methylguanosine MSDS(Chinese)

RIDADR	NONH for all modes of transport

Precursor 5
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