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2'-C-Methylguanosine

Names

[ CAS No. ]:
374750-30-8

[ Name ]:
2'-C-Methylguanosine

[Synonym ]:
2`-C-Beta-Methyl Guanosine
2'-METHYLGUANOSINE
2'-C-Methylguanosine
Guanosine, 2'-C-methyl-
2-amino-9-(2-C-methyl-β-D-ribofuranosyl)-9H-purin-6-ol
9H-purin-6-ol, 2-amino-9-(2-C-methyl-β-D-ribofuranosyl)-

Biological Activity

[Description]:

2'-C-Methylguanosine (2'-C-beta-Methylguanosine) is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.  

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
733.1±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H15N5O5

[ Molecular Weight ]:
297.27

[ Flash Point ]:
397.2±35.7 °C

[ Exact Mass ]:
297.107330

[ PSA ]:
159.51000

[ LogP ]:
0.34

[ Appearance of Characters ]:
white to beige

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.860

[ Storage condition ]:
?20°C

[ Water Solubility ]:
H2O: soluble5mg/mL, clear (warmed)

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Precursor & DownStream

Precursor

DownStream

Related Compounds