N-2-Acetylguanine

Names

[ CAS No. ]:
19962-37-9

[ Name ]:
N-2-Acetylguanine

[Synonym ]:
2-Acetamido-6-hydroxypurine
N2-Acetylguanine
N2-acetylguanidine
N-2-Acetylguanine
MFCD00078201
N-Acetylguanine
2-acetylamino-6-hydroxypurine
2-N-Acetylguanine
EINECS 243-443-7

Biological Activity

[Description]:

N2-Acetylguanine is a C2-modified guanine. N2-Acetylguanine binds GR (guanine-guanine riboswitch) with an Kd value of 300 nM. N2-Acetylguanine modulate transcriptional termination. N2-Acetylguanine has the potential for the research of antimicrobial agent[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[In Vitro]

N2-Acetylguanine completely disrupt a key Watson–Crick pairing interaction between the ligand and RNA[1]. N2-Acetylguanine (20 µM) promotes transcriptional termination in Bacillus subtilis [1].

[References]

[1]. Matyjasik MM, et al. High Affinity Binding of N2-Modified Guanine Derivatives Significantly Disrupts the Ligand Binding Pocket of the Guanine Riboswitch. Molecules. 2020 May 13;25(10):2295.

Chemical & Physical Properties

[ Density]:
1.83 g/cm3

[ Melting Point ]:
260 °C

[ Molecular Formula ]:
C₇H₇N₅O₂

[ Molecular Weight ]:
193.16300

[ Exact Mass ]:
193.06000

[ PSA ]:
103.53000

[ Index of Refraction ]:
1.833

[ Storage condition ]:
Refrigerator

[ Water Solubility ]:
practically insoluble

MSDS

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Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ HS Code ]:
2933990090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%