2-Amino-6-chloropurine
Names
[ CAS No. ]:
10310-21-1
[ Name ]:
2-Amino-6-chloropurine
[Synonym ]:
2-Amino-6-Chloro-Purin
2-Amino-6-chloropurine
MFCD00075252
EINECS 233-686-7
6-Chloroguanine
9H-Purin-2-amine, 6-chloro-
6-Chloro-3H-purin-2-amine
2-AMINO-6-CHLORO-PURINE
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
[References]
Chemical & Physical Properties
[ Density]:
1.8±0.1 g/cm3
[ Boiling Point ]:
315.2ºC at 760mmHg
[ Melting Point ]:
>300 °C(lit.)
[ Molecular Formula ]:
C5H4ClN5
[ Molecular Weight ]:
169.57
[ Flash Point ]:
144.4ºC
[ Exact Mass ]:
169.015518
[ PSA ]:
80.48000
[ LogP ]:
-0.03
[ Vapour Pressure ]:
1.75E-15mmHg at 25°C
[ Index of Refraction ]:
1.827
[ Storage condition ]:
Keep Cold
[ Water Solubility ]:
1.7 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UO7502000
- CHEMICAL NAME :
- Purine, 2-amino-6-chloro-
- CAS REGISTRY NUMBER :
- 10310-21-1
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C5-H4-Cl-N5
- MOLECULAR WEIGHT :
- 169.59
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 20 mg/L/24H
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 139,149,1984
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi,Xn
[ Risk Phrases ]:
R20/21/22
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
UO7502000
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Bioorg. Med. Chem. 15 , 3450-6, (2007)
Xanthine oxidase (XO) is a key enzyme which can catalyze xanthine to uric acid causing hyperuricemia in humans. By using the fractionation technique and inhibitory activity assay, an active compound t...
Molecular crowding enhances facilitated diffusion of two human DNA glycosylases.Nucleic Acids Res. 43 , 4087-97, (2015)
Intracellular space is at a premium due to the high concentrations of biomolecules and is expected to have a fundamental effect on how large macromolecules move in the cell. Here, we report that crowd...
Additive Pummerer reaction of 3,5-O-(di-tert-butyl)silylene-4-thiofuranoid glycal: a high-yield and beta-selective entry to 4'-thioribonucleosides.J. Org. Chem. 74(6) , 2616-9, (2009)
Upon reacting 3,5-O-(di-tert-butyl)silylene-4-thiofuranoid glycal S-oxide (6) with Ac(2)O/TMSOAc/BF(3) x OEt(2) in CH(2)Cl(2), the additive Pummerer reaction proceeded to furnish the corresponding 1,2...