Guanine

Names

[ CAS No. ]:
73-40-5

[ Name ]:
Guanine

[Synonym ]:
MFCD00071533
dewpearl
Guanin
2-amino-Hypoxanthine
9H-purin-6-ol, 2-amino-
2-amino-3,7-dihydro-6H-purin-6-one
7H-Purin-6-ol, 2-amino-
Guanine
2-amino-9H-purin-6-ol
Guanie
2-amino-6-oxypurine
Gua
guamine
EINECS 200-799-8
2-amino-1,7-dihydro-6H-purin-6-one
2-amino-1,9-dihydro-6H-purin-6-one
quanine
2-amino-6-hydroxypurine
Ganciclovir Impurity 6

Biological Activity

[Description]:

Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Research Areas >> Cancer

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
2.2±0.1 g/cm3

[ Boiling Point ]:
561.5±42.0 °C at 760 mmHg

[ Melting Point ]:
>300 °C(lit.)

[ Molecular Formula ]:
C₅H₅N₅O

[ Molecular Weight ]:
151.126

[ Flash Point ]:
293.4±27.9 °C

[ Exact Mass ]:
151.049408

[ PSA ]:
100.45000

[ LogP ]:
-2.03

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
2.047

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
practically insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF8260000

CHEMICAL NAME :: Guanine

CAS REGISTRY NUMBER :: 73-40-5

LAST UPDATED :: 199709

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C5-H5-N5-O

MOLECULAR WEIGHT :: 151.15

WISWESSER LINE NOTATION :: T56 BM DN FVM INJ HZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3333 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1300 mg/kg/26W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - ovarian tumors

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

REFERENCE :: NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958- Volume(issue)/page/year: 19,40,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2576 No. of Facilities: 1778 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 4133 (estimated) No. of Female Employees: 3339 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MF8260000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

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