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7-Methylguanine

Names

[ CAS No. ]:
578-76-7

[ Name ]:
7-Methylguanine

[Synonym ]:
6H-Purin-6-one, 2-amino-1,7-dihydro-7-methyl-
2-amino-7-methyl-3H-purin-6-one
2-Amino-7-methyl-1,7-dihydro-6H-purin-6-one
7-methyl-Guanine (8CI)
7-N-methylguanine
N(sup 7)-Methylguanine
7-methyl-Guanine
Epiguanine
2-Amino-7-methylhypoxanthine
N7-Methylguanine
7-Methylguanine
2-amino-7-methyl-1,7-dihydro-purin-6-one
2-Amino-1,7-dihydro-7-methyl-6H-purin-6-one
GUANINE,7-METHYL
2-Amino-6-hydroxy-7-methylpurine

Biological Activity

[Description]:

7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents, and used as a probe of protein–DNA interactions and a key component of DNA sequencing method.

[Related Catalog]:

Natural Products >> Others
Research Areas >> Others

[Target]

Human Endogenous Metabolite


[References]

[1]. Lee S, et al. Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. J Am Chem Soc. 2008 Sep 3;130(35):11570-1.


[Related Small Molecules]

3-Methyladenine | Hydrocortisone | Acetylcysteine(N-acetylcysteine) | Retinoic acid | Melatonine | Dinoprostone | Nicotinamide | Adenosine triphosphate | 4-Acetamidophenol | Prostaglandin E1 | Dehydroepiandrosterone | Corticosterone | Progesterone | Docosahexaenoic Acid | NAD+

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
481.4±37.0 °C at 760 mmHg

[ Melting Point ]:
370°C

[ Molecular Formula ]:
C6H7N5O

[ Molecular Weight ]:
165.153

[ Flash Point ]:
244.9±26.5 °C

[ Exact Mass ]:
165.065063

[ PSA ]:
89.59000

[ LogP ]:
-2.08

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.865

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MF8464000
CHEMICAL NAME :
Guanine, 7-methyl-
CAS REGISTRY NUMBER :
578-76-7
LAST UPDATED :
199206
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C6-H7-N5-O
MOLECULAR WEIGHT :
165.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Phage inhibition capacity
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
1 gm/L
REFERENCE :
ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.1- 1960- Volume(issue)/page/year: 12,583,1972

Safety Information

[ Hazard Codes ]:
Xi

[ WGK Germany ]:
3

[ RTECS ]:
MF8464000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds