Chloromethane
Names
[ CAS No. ]:
74-87-3
[ Name ]:
Chloromethane
[Synonym ]:
Methane, chloro-
Artic
Freon 40
EINECS 200-817-4
METHYL CHLORIDE
MFCD00000872
MONOCHLOROMETHANE
Chloride, Methyl
Chloromethane
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
-24.5±3.0 °C at 760 mmHg
[ Melting Point ]:
-97ºC
[ Molecular Formula ]:
CH3Cl
[ Molecular Weight ]:
50.487
[ Flash Point ]:
-86.4±2.8 °C
[ Exact Mass ]:
49.992329
[ LogP ]:
0.97
[ Vapour density ]:
1.74 (vs air)
[ Vapour Pressure ]:
4074.1±0.0 mmHg at 25°C
[ Index of Refraction ]:
1.331
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- PA6300000
- CHEMICAL NAME :
- Methane, chloro-
- CAS REGISTRY NUMBER :
- 74-87-3
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 70
- MOLECULAR FORMULA :
- C-H3-Cl
- MOLECULAR WEIGHT :
- 50.49
- WISWESSER LINE NOTATION :
- G1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 20000 ppm/2H
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5300 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2200 ppm/6H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 14661 ppm/6H
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature increase
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 129 mg/m3/4H
- TOXIC EFFECTS :
- Behavioral - general anesthetic Lungs, Thorax, or Respiration - respiratory depression
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 20000 ppm/2H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3000 ppm/6H/5D-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 41 mg/m3/4H/26W-I
- TOXIC EFFECTS :
- Liver - liver function tests impaired Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 ppm/22H/11D-C
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Endocrine - changes in thymus weight Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 500 ppm/24H/3D-C
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Behavioral - tremor Behavioral - ataxia
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 2000 ppm/6H
- SEX/DURATION :
- male 5 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 1500 ppm/6H
- SEX/DURATION :
- male 50 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 1500 ppm/6H
- SEX/DURATION :
- female 7-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 3000 ppm/6H
- SEX/DURATION :
- male 5 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 3000 ppm/6H
- SEX/DURATION :
- male 5 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 500 ppm/6H
- SEX/DURATION :
- female 6-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 750 ppm/6H
- SEX/DURATION :
- female 6-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- Dominant lethal test
MUTATION DATA
- TYPE OF TEST :
- Morphological transformation
- TEST SYSTEM :
- Rodent - hamster Embryo
- REFERENCE :
- EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1972- Volume(issue)/page/year: 25,75,1982 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 207 mg/m3 (100 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 103 mg/m3 (50 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,161,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,161,1986 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,246,1987 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD:air-CL 100 ppm (210 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,160,1971 OSHA PEL (Gen Indu):8H TWA 100 ppm;CL 200;Pk 300/5M/3H CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 100 ppm (210 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 100 ppm (210 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):CL 100 ppm (210 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 50 ppm (105 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 50 ppm (105 mg/m3);STEL 100 ppm (205 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 50 ppm (105 mg/m3) JAN 1993 OEL-BELGIUM:TWA 50 ppm (103 mg/m3);STEL 100 ppm (207 mg/m3) JAN 1993 OEL-DENMARK:TWA 50 ppm (105 mg/m3) JAN 1993 OEL-FINLAND:TWA 50 ppm (105 mg/m3);STEL 75 ppm (160 mg/m3) JAN 1993 OEL-FRANCE:TWA 50 ppm (105 mg/m3);STEL 100 ppm (210 mg/m3) JAN 1993 OEL-GERMANY:TWA 50 ppm (105 mg/m3);Carcinogen JAN 1993 OEL-HUNGARY:TWA 20 mg/m3;STEL 40 mg/m3 JAN 1993 OEL-JAPAN:TWA 50 ppm (100 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 50 ppm (105 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 100 ppm (210 mg/m3) JAN 1993 OEL-POLAND:TWA 20 mg/m3 JAN 1993 OEL-RUSSIA:TWA 50 ppm;STEL 5 mg/m3 JAN 1993 OEL-SWEDEN:TWA 50 ppm (100 mg/m3);STEL 100 ppm (200 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 50 ppm (105 mg/m3);STEL 100 ppm (210 mg/m3) JAN 1993 OEL-THAILAND:TWA 100 mg/m3;STEL 200 mg/m3 JAN 1993 OEL-TURKEY:TWA 100 ppm (210 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 50 ppm (105 mg/m3);STEL 100 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL CHLORIDE-air:CA lowest feasible concentration REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0421 No. of Facilities: 1937 (estimated) No. of Industries: 32 No. of Occupations: 29 No. of Employees: 8804 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0421 No. of Facilities: 596 (estimated) No. of Industries: 18 No. of Occupations: 38 No. of Employees: 10003 (estimated) No. of Female Employees: 571 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS07, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H315-H351-H361fd
[ Supplemental HS ]:
May form explosive peroxides., Repeated exposure may cause skin dryness or cracking.
[ Precautionary Statements ]:
P210-P281
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
F+;Xn
[ Risk Phrases ]:
R12
[ Safety Phrases ]:
9-16-33
[ RIDADR ]:
UN 1993 3
[ WGK Germany ]:
2
[ RTECS ]:
PA6300000
[ Hazard Class ]:
2.1
[ HS Code ]:
2903110000
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2903110000
[ Summary ]:
2903110000 chloroethane。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:5.5%。General tariff:30.0%
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