NAD+

Names

[ CAS No. ]:
53-84-9

[ Name ]:
NAD+

[Synonym ]:
b-Diphosphopyridine Nucleotide
DPN
beta-Diphosphopyrid
MFCD00036253
Coenzyme I Hydrate,oxidized form
Diphosphopyridine nucleotide
Cozymase Hydrate,oxidized form
β-Nicotinamide adenine dinucleotide
EINECS 200-184-4
β-Diphosphopyridine Nucleotide Hydrate,oxidized form
β-NAD Hydrate,oxidized form
Adenine-D-ribose-phosphate-phosphate-D-ribose-nicotinamide
b-Nicotinamide Adenine Dinucleotide
β-DPN Hydrate,oxidized form
Adenosine 5'-(Trihydrogen Diphosphate) P'®5'-ester with 3-(Aminocarbonyl)-1-b-D-ribofuranosylpyridinium hydroxide Inner Salt
Codehydrogenase
β-Nicotinamide Adenine Dinucleotide Hydrate,oxidized form
3-Carbamoyl-1-b-D-ribofuranosylpyridinium hydroxide 5'®5'-ester with Adenosine 5'-(Trihydrogen Pyrophosphate) Inner Salt
ARPPRN
b-NAD
Cozymase
beta-Diphosphopyridine nucleotide
β-NAD
β-Nicotinamide adenine dinucleotide hydrate
NAD
β-DPN
NAD+

Biological Activity

[Description]:

NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

[Related Catalog]:

Research Areas >> Metabolic Disease

Natural Products >> Saccharides and Glycosides

[Target]

Human Endogenous Metabolite

[In Vitro]

NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. NAD+ is the oxidized form of NADH[1]. NAD+ is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (Nadide) [2].

[In Vivo]

Oral NAD+ supplementation has been used to combat simple fatigue as well as such mysterious and energy-sapping disorders as chronic fatigue syndrome and fibromyalgia[3].

[References]

[1]. Viollet, B., et al., Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond), 2012. 122(6): p. 253-70.

[2]. Brandt, U., Energy converting NADH:quinone oxidoreductase (complex I). Annu Rev Biochem, 2006. 75: p. 69-92.

[3]. Kussmaul, L. and J. Hirst, The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc Natl Acad Sci U S A, 2006. 103(20): p. 7607-12.

[Related Small Molecules]

Chemical & Physical Properties

[ Melting Point ]:
140 - 142ºC

[ Molecular Formula ]:
C₂₁H₂₇N₇O₁₄P₂

[ Molecular Weight ]:
663.425

[ Exact Mass ]:
663.109131

[ PSA ]:
340.71000

[ LogP ]:
-5.72

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU3450000

CHEMICAL NAME :: Pyridinium, 3-carbamoyl-1-beta-D-ribofuranosyl-, hydroxide, 5'-ester with adenosine 5'- 5'-(trihydrogen pyrophosphate), inner salt

CAS REGISTRY NUMBER :: 53-84-9

BEILSTEIN REFERENCE NO. :: 3584133

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C21-H27-N7-O14-P2

MOLECULAR WEIGHT :: 663.49

WISWESSER LINE NOTATION :: T56 BN DN GN INJ FZ B- BT5OJ CQ DQ E1OPWOPWO1- BT5OTJ CQ DQ E- AT6KJ CVZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4333 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 45,327,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3384 No. of Facilities: 499 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 4168 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3384 No. of Facilities: 1731 (estimated) No. of Industries: 5 No. of Occupations: 13 No. of Employees: 26664 (estimated) No. of Female Employees: 19782 (estimated)

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H371

[ Precautionary Statements ]:
P260

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn,F,Xi

[ Risk Phrases ]:
R36

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UU3450000

[ HS Code ]:
29349990

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 29349990

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