β-Nicotinamide mononucleotide

Names

[ Name ]:
β-Nicotinamide mononucleotide

[Synonym ]:
3-Carbamoyl-1-[5-O-(hydroxyphosphinato)-β-D-ribofuranosyl]pyridinium
MFCD00038748
Beta-Nicotinamide Mononucleotide
pyridinium, 3-(hydroxyiminomethyl)-1-(5-O-phosphono-β-D-ribofuranosyl)-, inner salt
Nicotinamide D-ribonucleotide
3-(Aminocarbonyl)-1-(5-O-phosphono-b-D-ribofuranosyl)pyridinium Hydroxide Inner Salt
NMN zwitterion
EINECS 214-136-5
β-nicotinamide mononucleotide
3-Carbamoyl-1-b-D-ribofuranosylpyridinium Hydroxide 5'-(Dihydrogen Phosphate) Inner Salt
Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-β-D-ribofuranosyl)-, inner salt
[(2R,3S,4R,5R)-5-(3-Carbamoyl-1-pyridiniumyl)-3,4-dihydroxytetrahydro-2-furanyl]methyl hydrogen phosphate
beta-NMN
Nicotinamide ribonucleotide
NMN

Biological Activity

[Description]:

β-nicotinamide mononucleotide is an intermediate in NAD+ biosynthesis produced from nicotinamide (NAM) and phosphoribosyl pyrophosphate (PRPP) by nicotinamide phosphoribosyl transferase enzyme.

[Related Catalog]:

Natural Products >> Saccharides and Glycosides

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₅N₂O₈P

[ Molecular Weight ]:
334.219

[ Exact Mass ]:
334.056610

[ PSA ]:
176.06000

[ LogP ]:
-3.38

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Lipopolysaccharide Regulation of Intestinal Tight Junction Permeability Is Mediated by TLR4 Signal Transduction Pathway Activation of FAK and MyD88.

J. Immunol. 195 , 4999-5010, (2015)

Gut-derived bacterial LPS plays an essential role in inducing intestinal and systemic inflammatory responses and have been implicated as a pathogenic factor in necrotizing enterocolitis and inflammato...

A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis.

Pharmacol. Res. 62(1) , 42-7, (2010)

Aging science has recently drawn much attention, and discussions on the possibility of anti-aging medicine have multiplied. One potential target for the development of anti-aging drugs is the SIR2 (si...

The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism.

Biochem. J. 441(1) , 131-41, (2012)

Haemophilus influenzae is a major pathogen of the respiratory tract in humans that has developed the capability to exploit host NAD(P) for its nicotinamide dinucleotide requirement. This strategy is o...