Adenosine triphosphate

Names

[ CAS No. ]:
56-65-5

[ Name ]:
Adenosine triphosphate

[Synonym ]:
atipi
Fosfobion
Adenosine tetrahydrogen triphosphate
Adenosine, 5'-(tetrahydrogen triphosphate)
adenosine-triphosphate
Striphos
Adenosine 5'-triphosphorate
Triadesin A
adetol
Adenosine 5'-(tetrahydrogen triphosphate)
Triphosadenine
adephos
MFCD00065467
EINECS 200-283-2
Adenosine triphosphate
Adenosine-5'-triphosphate
Adetide
5'-Atp
adynol
striadyne
Adenosinetriphosphate
atriphos
adenosine-5′-triphosphate
adenosine 5'-triphosphoric acid
Adenosine 5'-triphosphate
Cardenosine
adenosine 5′-triphosphate
Phosphobion
ATP
Adenphos

Biological Activity

[Description]:

ATP is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells.

[Related Catalog]:

Natural Products >> Others

Research Areas >> Neurological Disease

[Target]

Human Endogenous Metabolite

[In Vitro]

ATP (100-300 µM) inhibits the production of TNF-α by 32±8%, and at 300 µM, the attenuation of TNF-α production is 65±4% in LPS + PHA-stimulated whole blood. ATP (100, 300 µM) increases IL-10 levels by 48±5% (p=0.01) and 62±7%, respectively, in LPS + PHA-stimulated whole blood. ATP does not significantly alter the production of IL-6.

[References]

[1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
2.6±0.1 g/cm3

[ Boiling Point ]:
951.4±75.0 °C at 760 mmHg

[ Melting Point ]:
187 - 190ºC (Decomposes)

[ Molecular Formula ]:
C₁₀H₁₆N₅O₁₃P₃

[ Molecular Weight ]:
507.181

[ Flash Point ]:
529.2±37.1 °C

[ Exact Mass ]:
506.995758

[ PSA ]:
308.56000

[ LogP ]:
-4.18

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.904

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7416000

CHEMICAL NAME :: Adenosine 5'-(tetrahydrogen triphosphate)

CAS REGISTRY NUMBER :: 56-65-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C10-H16-N5-O13-P3

MOLECULAR WEIGHT :: 507.22

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ IZ D- BT5OTJ CQ DQ E1OPQO&OPQO&OPQQO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 2 umol/L

REFERENCE :: CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 27,61,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3124 No. of Facilities: 351 (estimated) No. of Industries: 1 No. of Occupations: 8 No. of Employees: 6576 (estimated) No. of Female Employees: 5259 (estimated)

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.