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Adenosine triphosphate

Names

[ CAS No. ]:
56-65-5

[ Name ]:
Adenosine triphosphate

[Synonym ]:
atipi
Fosfobion
Adenosine tetrahydrogen triphosphate
Adenosine, 5'-(tetrahydrogen triphosphate)
adenosine-triphosphate
Striphos
Adenosine 5'-triphosphorate
Triadesin A
adetol
Adenosine 5'-(tetrahydrogen triphosphate)
Triphosadenine
adephos
MFCD00065467
EINECS 200-283-2
Adenosine triphosphate
Adenosine-5'-triphosphate
Adetide
5'-Atp
adynol
striadyne
Adenosinetriphosphate
atriphos
adenosine-5′-triphosphate
adenosine 5'-triphosphoric acid
Adenosine 5'-triphosphate
Cardenosine
adenosine 5′-triphosphate
Phosphobion
ATP
Adenphos

Biological Activity

[Description]:

ATP is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells.

[Related Catalog]:

Natural Products >> Others
Research Areas >> Neurological Disease

[Target]

Human Endogenous Metabolite


[In Vitro]

ATP (100-300 µM) inhibits the production of TNF-α by 32±8%, and at 300 µM, the attenuation of TNF-α production is 65±4% in LPS + PHA-stimulated whole blood. ATP (100, 300 µM) increases IL-10 levels by 48±5% (p=0.01) and 62±7%, respectively, in LPS + PHA-stimulated whole blood. ATP does not significantly alter the production of IL-6.

[References]

[1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8.


[Related Small Molecules]

3-Methyladenine | Hydrocortisone | Acetylcysteine(N-acetylcysteine) | Retinoic acid | Melatonine | Dinoprostone | Nicotinamide | 4-Acetamidophenol | Prostaglandin E1 | Dehydroepiandrosterone | Corticosterone | Progesterone | Docosahexaenoic Acid | NAD+ | Substance P acetate salt

Chemical & Physical Properties

[ Density]:
2.6±0.1 g/cm3

[ Boiling Point ]:
951.4±75.0 °C at 760 mmHg

[ Melting Point ]:
187 - 190ºC (Decomposes)

[ Molecular Formula ]:
C10H16N5O13P3

[ Molecular Weight ]:
507.181

[ Flash Point ]:
529.2±37.1 °C

[ Exact Mass ]:
506.995758

[ PSA ]:
308.56000

[ LogP ]:
-4.18

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.904

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AU7416000
CHEMICAL NAME :
Adenosine 5'-(tetrahydrogen triphosphate)
CAS REGISTRY NUMBER :
56-65-5
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C10-H16-N5-O13-P3
MOLECULAR WEIGHT :
507.22
WISWESSER LINE NOTATION :
T56 BN DN FN HNJ IZ D- BT5OTJ CQ DQ E1OPQO&OPQO&OPQQO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2780 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
2 umol/L
REFERENCE :
CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 27,61,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3124 No. of Facilities: 351 (estimated) No. of Industries: 1 No. of Occupations: 8 No. of Employees: 6576 (estimated) No. of Female Employees: 5259 (estimated)

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds