LMI070

Names

[ Name ]:
LMI070

[Synonym ]:
branaplam
P12R69543A
Phenol, 5-(1H-pyrazol-4-yl)-2-[6-[(2,2,6,6-tetramethyl-4-piperidinyl)oxy]-3-pyridazinyl]-
5-(1H-Pyrazol-4-yl)-2-{6-[(2,2,6,6-tetramethyl-4-piperidinyl)oxy]-3-pyridazinyl}phenol
LMI070

Biological Activity

[Description]:

LMI070 (Branaplam) is a highly potent, selective and orally active small molecule SMN2 splicing modulator.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Research Areas >> Cancer

[References]

[1]. Palacino J, et al. SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice. Nat Chem Biol. 2015 Jul;11(7):511-517.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
660.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₇N₅O₂

[ Molecular Weight ]:
393.482

[ Flash Point ]:
353.0±31.5 °C

[ Exact Mass ]:
393.216461

[ LogP ]:
2.86

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.576

[ Storage condition ]:
-20℃

Related Compounds

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