Dihydrofolic acid

[Description]:

[Related Catalog]:

[Target]

[Related Small Molecules]

[ Density]:
1.69g/cm3

[ Molecular Formula ]:
C₁₉H₂₁N₇O₆

[ Molecular Weight ]:
443.41300

[ Exact Mass ]:
443.15500

[ PSA ]:
211.89000

[ LogP ]:
0.62870

[ Index of Refraction ]:
1.762

[ Storage condition ]:
-20°C

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

Click to get detail synthetic route

Precursor

DownStream

Synthetic polyglutamylation of dual-functional MTX ligands for enhanced combined cytotoxicity of poly(I:C) nanoplexes.

Mol. Pharm. 11(8) , 2631-9, (2014)

The antifolate drug methotrexate (MTX) can serve as a dual-functional ligand in antitumoral drug delivery, inducing both a folate receptor mediated cellular uptake and an intracellular cytotoxic actio...

A domino effect in antifolate drug action in Escherichia coli.

Nat. Chem. Biol. 4 , 602-8, (2008)

Mass spectrometry technologies for measurement of cellular metabolism are opening new avenues to explore drug activity. Trimethoprim is an antibiotic that inhibits bacterial dihydrofolate reductase (D...

Methotrexate-gelonin conjugate - an inhibitor of MCF-7 cells expressing the dihydrofolate receptor.

Biol. Chem. 395(12) , 1461-6, (2014)

An immunotoxin composed of gelonin, a basic ribosome-inactivating protein, type I of 30 kDa, isolated from the seeds of the Indian plant Gelonium multiflorum and methotrexate (MTX) has been studied as...

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