Dihydrofolic acid
Dihydrofolic acid structure
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Common Name | Dihydrofolic acid | ||
|---|---|---|---|---|
| CAS Number | 4033-27-6 | Molecular Weight | 443.41300 | |
| Density | 1.69g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C19H21N7O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Synthetic polyglutamylation of dual-functional MTX ligands for enhanced combined cytotoxicity of poly(I:C) nanoplexes.
Mol. Pharm. 11(8) , 2631-9, (2014) The antifolate drug methotrexate (MTX) can serve as a dual-functional ligand in antitumoral drug delivery, inducing both a folate receptor mediated cellular uptake and an intracellular cytotoxic action. Bioactivity of MTX however changes by conjugation; the a... |
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A domino effect in antifolate drug action in Escherichia coli.
Nat. Chem. Biol. 4 , 602-8, (2008) Mass spectrometry technologies for measurement of cellular metabolism are opening new avenues to explore drug activity. Trimethoprim is an antibiotic that inhibits bacterial dihydrofolate reductase (DHFR). Kinetic flux profiling with (15)N-labeled ammonia in ... |
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Methotrexate-gelonin conjugate - an inhibitor of MCF-7 cells expressing the dihydrofolate receptor.
Biol. Chem. 395(12) , 1461-6, (2014) An immunotoxin composed of gelonin, a basic ribosome-inactivating protein, type I of 30 kDa, isolated from the seeds of the Indian plant Gelonium multiflorum and methotrexate (MTX) has been studied as a potential tool of gelonin delivery into the cytoplasm of... |
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Controlling enzyme inhibition using an expanded set of genetically encoded amino acids.
Biotechnol. Bioeng. 110(9) , 2361-70, (2013) Enzyme inhibition plays an important role in drug development, metabolic pathway regulation, and biocatalysis with product inhibition. When an inhibitor has high structural similarities to the substrate of an enzyme, controlling inhibitor binding without affe... |
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[Photobiochemistry of folates: a photochemical reduction of folic acid].
Prikl. Biokhim. Mikrobiol. 46(3) , 372-8, (2010) Exposure of deaerated folic acid solutions containing an electron donor to UV radiation (310-390 nm, I = 0.4 W m(-2)) induced formation of dihydrofolic acid (DHFA), a photoexcitation which gave tetrahydrofolic acid (THFA). Only DHFA was formed in the presence... |
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pH-Dependent radical scavenging activity of folates.
J. Agric. Food Chem. 55(20) , 8237-42, (2007) Folic acid (FA) is used, in many countries, in nutritional supplements or for the fortification of cereals and their products. It is also used in vitamin pills. Recently, it was reported that folates may act as antioxidants; therefore, in the present study, t... |
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Conformation coupled enzyme catalysis: single-molecule and transient kinetics investigation of dihydrofolate reductase.
Biochemistry 44(51) , 16835-43, (2005) Ensemble kinetics and single-molecule fluorescence microscopy were used to study conformational transitions associated with enzyme catalysis by dihydrofolate reductase (DHFR). The active site loop of DHFR was labeled with a fluorescence quencher, QSY35, at am... |
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Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent manner.
Endocr. Relat. Cancer 13(2) , 571-81, (2006) The insulin-like growth factor-I receptor (IGF-IR) has an important role in colorectal cancer development and progression. IGF-IR displays a potent anti-apoptotic activity and is overexpressed in primary tumors and colon cancer-derived cell lines. Folic acid,... |
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QM/MM study of thymidylate synthase: enzymatic motions and the temperature dependence of the rate limiting step.
J. Phys. Chem. A 113(10) , 2176-82, (2009) Thymidylate synthase (TS) is an enzyme that catalyzes a complex cascade of reactions. A theoretical study of the reduction of an exocyclic methylene intermediate by hydride transfer from the 6S position of 5,6,7,8-tetrahydrofolate (H(4)folate), to form 2'-deo... |
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Tuning of the H-transfer coordinate in primitive versus well-evolved enzymes.
ChemPhysChem 9(7) , 980-2, (2008)
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