5-Methyluridine

Names

[ Name ]:
5-Methyluridine

[Synonym ]:
5-Methyl Uridine
5-methyl-1-β-D-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione
5-methyl-D-uridine
ribothymidine
1-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidindion
5-Methyl-1-pentofuranosyl-2,4(1H,3H)-pyrimidinedione
Thymine riboside
5-Methyl-1-pentofuranosylpyrimidine-2,4(1H,3H)-dione
Uridine, 5-methyl-
1-[3,4-Dihydroxy-5-(hydroxyméthyl)tétrahydro-2-furanyl]-5-méthyl-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-pentofuranosyl-
1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
EINECS 215-973-9
5-methyl-Uridine
1-b-D-Ribofuranosylthymine
Ribosylthymine
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
1-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
5-Methyl-1-(β-D-ribofuranosyl)pyrimidin-2,4(1H,3H)-dion
MFCD00006535
5MU
5-Methyluridine

Biological Activity

[Description]:

5-Methyluridine is a is an endogenous methylated nucleoside found in human fluids.

[Related Catalog]:

Natural Products >> Alkaloid

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Yang TH, et al. Intracellular levels of S-adenosylhomocysteine but not homocysteine are highly correlated to the expression of nm23-H1 and the level of 5-methyldeoxycytidine in human hepatoma cells with different invasion activities. Nutr Cancer. 2006;55(2):224-31.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Melting Point ]:
183-184 °C(lit.)

[ Molecular Formula ]:
C₁₀H₁₄N₂O₆

[ Molecular Weight ]:
258.228

[ Exact Mass ]:
258.085175

[ PSA ]:
124.78000

[ LogP ]:
-1.02

[ Index of Refraction ]:
1.619

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
T+: Very toxic;

[ Risk Phrases ]:
R26/27/28

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Metabolome analysis via comprehensive two-dimensional liquid chromatography: identification of modified nucleosides from RNA metabolism.

Anal. Bioanal. Chem 407(13) , 3555-66, (2015)

Modified nucleosides derived from the RNA metabolism constitute an important chemical class, which are discussed as potential biomarkers in the detection of mammalian breast cancer. Not only the varia...

Exometabolom analysis of breast cancer cell lines: Metabolic signature.

Sci. Rep. 5 , 13374, (2015)

Cancer cells show characteristic effects on cellular turnover and DNA/RNA modifications leading to elevated levels of excreted modified nucleosides. We investigated the molecular signature of differen...

Least absolute shrinkage and selection operator and dimensionality reduction techniques in quantitative structure retention relationship modeling of retention in hydrophilic interaction liquid chromatography.

J. Chromatogr. A. 1403 , 54-62, (2015)

The objective of this study was to model the retention of nucleosides and pterins in hydrophilic interaction liquid chromatography (HILIC) via QSRR-based approach. Two home-made (Amino-P-C18, Amino-P-...