5-Fluorouridine
Names
[ CAS No. ]:
316-46-1
[ Name ]:
5-Fluorouridine
[Synonym ]:
L-5-Fluorouridine
FURD
5-fluoro-uridine
FUR
5-FLUOROIDINE
5-fur
5-Fluor-uridin
EINECS 206-260-3
MFCD00036832
5-Fluorouridine
5-FUrd
5-fluoro-uridin
1-(β-D-Ribofuranosyl)-5-fluorouracil
Uridine, 5-fluoro-
FLUOROURIDINE
5-FU
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.8±0.1 g/cm3
[ Melting Point ]:
182-184 °C
[ Molecular Formula ]:
C9H11FN2O6
[ Molecular Weight ]:
262.192
[ Exact Mass ]:
262.060120
[ PSA ]:
124.78000
[ LogP ]:
-1.34
[ Index of Refraction ]:
1.641
[ Water Solubility ]:
soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YU8050000
- CHEMICAL NAME :
- Uridine, 5-fluoro-
- CAS REGISTRY NUMBER :
- 316-46-1
- BEILSTEIN REFERENCE NO. :
- 0033662
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C9-H11-F-N2-O6
- MOLECULAR WEIGHT :
- 262.22
- WISWESSER LINE NOTATION :
- T6NVMVJ EF A- ET5OTJ B1Q CQ DQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 384 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- DNA inhibition
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - mouse Leukocyte
- DOSE/DURATION :
- 900 nmol/L
- REFERENCE :
- CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 49,2551,1984 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R40
[ Safety Phrases ]:
S22-S26-S36/37
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
YU8050000
[ HS Code ]:
2942000000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2942000000
Articles
J. Pharm. Biomed. Anal. 110 , 58-66, (2015)
5-Fluorouracil (5-FU) and its oral prodrug capecitabine are among the most widely used chemotherapeutics. For cytotoxic activity, 5-FU requires cellular uptake and intracellular metabolic activation. ...
N4-[Alkyl-(hydroxyphosphono)phosphonate]-cytidine—New drugs covalently linking antimetabolites (5-FdU, araU or AZT) with bone-targeting bisphosphonates (alendronate or pamidronate)Bioorg. Med. Chem. 19(11) , 3520-6, (2011)
New cytostatic antimetabolite-bisphosphonates.
Evidence for Transcriptional Activity in the Syncytiotrophoblast of the Human PlacentaPlacenta 30(4) , 329-34, (2009)
The aim was to test for evidence of transcriptional activity within the nuclei of the syncytiotrophoblast of the human placenta. The syncytiotrophoblast forms the epithelial covering of the villous tr...