5-Fluorouridine

Modify Date: 2024-01-02 09:46:04

5-Fluorouridine structure	Common Name	5-Fluorouridine
	CAS Number	316-46-1	Molecular Weight	262.192
	Density	1.8±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₉H₁₁FN₂O₆	Melting Point	182-184 °C
	MSDS	USA	Flash Point	N/A

Use of 5-Fluorouridine

5-Fluorouridine is a metabolite of 5-fluorouracil with anticancer activity[1][2][3][4]. 5-fluorouridine inhibits rRNA synthesis of human colon carcinoma cells[3]. 5-Fluorouridine exhibits cytotoxic effect on growth of L1210 cells with an IC50 of 2 nM[4].

Name	5-fluorouridine
Synonym	More Synonyms

Description	5-Fluorouridine is a metabolite of 5-fluorouracil with anticancer activity[1][2][3][4]. 5-fluorouridine inhibits rRNA synthesis of human colon carcinoma cells[3]. 5-Fluorouridine exhibits cytotoxic effect on growth of L1210 cells with an IC50 of 2 nM[4].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Wu FL , et al. Gelatinases-stimuli nanoparticles encapsulating 5-fluorouridine and 5-aza-2'-deoxycytidine enhance the sensitivity of gastric cancer cells to chemical therapeutics. Cancer Lett. 2015 Jul 10;363(1):7-16. [2]. Hu N, et al. Strengthening Gastric Cancer Therapy by Trastuzumab-Conjugated Nanoparticles with Simultaneous Encapsulation of Anti-MiR-21 and 5-Fluorouridine. Cell Physiol Biochem. 2017;44(6):2158-2173. [3]. Glazer RI, et al. Association of cell lethality with incorporation of 5-fluorouracil and 5-fluorouridine into nuclear RNA in human colon carcinoma cells in culture. Mol Pharmacol. 1982 Mar;21(2):468-73. [4]. Kanzawa F, et al. Differences between 5-fluoro-2'-deoxyuridine and 5-fluorouridine in their cytotoxic effect on growth of murine lymphoma L5178Y cells in in vivo and in vitro systems. Eur J Cancer. 1980 Aug;16(8):1087-92.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

References

[1]. Wu FL , et al. Gelatinases-stimuli nanoparticles encapsulating 5-fluorouridine and 5-aza-2'-deoxycytidine enhance the sensitivity of gastric cancer cells to chemical therapeutics. Cancer Lett. 2015 Jul 10;363(1):7-16.

[2]. Hu N, et al. Strengthening Gastric Cancer Therapy by Trastuzumab-Conjugated Nanoparticles with Simultaneous Encapsulation of Anti-MiR-21 and 5-Fluorouridine. Cell Physiol Biochem. 2017;44(6):2158-2173.

[3]. Glazer RI, et al. Association of cell lethality with incorporation of 5-fluorouracil and 5-fluorouridine into nuclear RNA in human colon carcinoma cells in culture. Mol Pharmacol. 1982 Mar;21(2):468-73.

[4]. Kanzawa F, et al. Differences between 5-fluoro-2'-deoxyuridine and 5-fluorouridine in their cytotoxic effect on growth of murine lymphoma L5178Y cells in in vivo and in vitro systems. Eur J Cancer. 1980 Aug;16(8):1087-92.

Density	1.8±0.1 g/cm3
Melting Point	182-184 °C
Molecular Formula	C₉H₁₁FN₂O₆
Molecular Weight	262.192
Exact Mass	262.060120
PSA	124.78000
LogP	-1.34
Index of Refraction	1.641
Water Solubility	soluble

5-Fluorouridine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU8050000

CHEMICAL NAME :: Uridine, 5-fluoro-

CAS REGISTRY NUMBER :: 316-46-1

BEILSTEIN REFERENCE NO. :: 0033662

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C9-H11-F-N2-O6

MOLECULAR WEIGHT :: 262.22

WISWESSER LINE NOTATION :: T6NVMVJ EF A- ET5OTJ B1Q CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 384 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 900 nmol/L

REFERENCE :: CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 49,2551,1984 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975

Personal Protective Equipment	Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R40
Safety Phrases	S22-S26-S36/37
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	YU8050000
HS Code	2942000000

Precursor 8
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DownStream 9
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CAS#:116696-69-6 sodium,[(2R)-2,...

HS Code	2942000000

Development of an LC-MS/MS assay for the quantitative determination of the intracellular 5-fluorouracil nucleotides responsible for the anticancer effect of 5-fluorouracil.

J. Pharm. Biomed. Anal. 110 , 58-66, (2015)

5-Fluorouracil (5-FU) and its oral prodrug capecitabine are among the most widely used chemotherapeutics. For cytotoxic activity, 5-FU requires cellular uptake and intracellular metabolic activation. ...

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New cytostatic antimetabolite-bisphosphonates.

Evidence for Transcriptional Activity in the Syncytiotrophoblast of the Human Placenta

Placenta 30(4) , 329-34, (2009)

The aim was to test for evidence of transcriptional activity within the nuclei of the syncytiotrophoblast of the human placenta. The syncytiotrophoblast forms the epithelial covering of the villous tr...

L-5-Fluorouridine

FURD

5-fluoro-uridine

FUR

5-FLUOROIDINE

5-fur

5-Fluor-uridin

EINECS 206-260-3

MFCD00036832

5-Fluorouridine

5-FUrd

5-fluoro-uridin

1-(β-D-Ribofuranosyl)-5-fluorouracil

Uridine, 5-fluoro-

FLUOROURIDINE

5-FU

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 5-Fluorouridine
Price: ￥348.0/5g
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-Fluorouridine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: 5-Fluorouridine
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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5-Fluorouridine

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