Azelaic acid

Names

[ CAS No. ]:
123-99-9

[ Name ]:
Azelaic acid

[Synonym ]:
Skinoren
AZALEIC ACID
Azelaate
3,4-Dimethoxybenzaldehyde
Nonanedioic acid
Azelaic acid
UNII-F2VW3D43YT
AZELAIC ACID/NONANEDIOIC ACID
Barasertib
AZELAIC ACID FOR SYNTHESIS
INH 34
Azelex
Azelaicacid
Finaceae
lepargylic acid
1,7-HEPTANE DICARBONIC ACID
1,7-HEPTANEDICARBOXYLIC
AZD1152-HQPA
Azelainic acid
HEPTANE-1,7-DICARBOXYLIC ACID
Azalaic Acid
AZELAIC ACID( MICRONIZED )
EINECS 204-669-1
anchoic acid
1,7-Heptanedicarboxylic acid
MFCD00004432

Biological Activity

[Description]:

Azelaic acid is an organic compound produced by the ozonolysis of oleic acid; component of a number of hair and skin conditioners.

[Related Catalog]:

Natural Products >> Acids and Aldehydes

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Jung HW, et al. Priming in systemic plant immunity. Science. 2009 Apr 3;324(5923):89-91.

[2]. Liu RH, et al. Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials. Arch Dermatol. 2006 Aug;142(8):1047-52.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
286 ºC (100 mmHg)

[ Melting Point ]:
98-103 ºC

[ Molecular Formula ]:
C₉H₁₆O₄

[ Molecular Weight ]:
188.221

[ Flash Point ]:
215 ºC

[ Exact Mass ]:
188.104858

[ PSA ]:
74.60000

[ LogP ]:
1.33

[ Vapour density ]:
6.5 (vs air)

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.475

[ Stability ]:
Stable. Combustible. Incompatible with bases, strong oxidizing agents. Readily biodegrades in soil and water with >70% DOC reduction after 28 days.

[ Water Solubility ]:
2.4 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CM1980000

CHEMICAL NAME :: Azelaic acid

CAS REGISTRY NUMBER :: 123-99-9

BEILSTEIN REFERENCE NO. :: 1101094

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C9-H16-O4

MOLECULAR WEIGHT :: 188.25

WISWESSER LINE NOTATION :: QV7VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: EMERY* Emery Industries, Inc., Data Sheets. (4900 Este Ave., Cincinnati, OH 45232) Volume(issue)/page/year: S3B,-,1964

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: EMERY* Emery Industries, Inc., Data Sheets. (4900 Este Ave., Cincinnati, OH 45232) Volume(issue)/page/year: S3B,-,1964 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-A067-313 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83495 No. of Facilities: 170 (estimated) No. of Industries: 8 No. of Occupations: 11 No. of Employees: 1676 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83495 No. of Facilities: 3427 (estimated) No. of Industries: 35 No. of Occupations: 42 No. of Employees: 34469 (estimated) No. of Female Employees: 7576 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
CM1980000

[ HS Code ]:
2917139000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2917139000

[ Summary ]:
2917139000 azelaic acid, sebacic acid, their salts and esters VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Physiology and pathophysiology of organic acids in cerebrospinal fluid.

J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)

Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

Related Compounds

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