Cyclooctanone
Names
[ CAS No. ]:
502-49-8
[ Name ]:
Cyclooctanone
[Synonym ]:
EINECS 207-940-2
MFCD00001754
Cyclooctanone
cyclooctan-1-one
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
193.2±8.0 °C at 760 mmHg
[ Melting Point ]:
32-41 °C(lit.)
[ Molecular Formula ]:
C8H14O
[ Molecular Weight ]:
126.196
[ Flash Point ]:
72.8±0.0 °C
[ Exact Mass ]:
126.104462
[ PSA ]:
17.07000
[ LogP ]:
1.89
[ Vapour Pressure ]:
0.5±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.448
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GX9800000
- CHEMICAL NAME :
- Cyclooctanone
- CAS REGISTRY NUMBER :
- 502-49-8
- BEILSTEIN REFERENCE NO. :
- 1280738
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C8-H14-O
- MOLECULAR WEIGHT :
- 126.22
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 740 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement Behavioral - coma Cardiac - arrhythmias (including changes in conduction)
- REFERENCE :
- COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 254,2245,1962
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
C:Corrosive;
[ Risk Phrases ]:
R34
[ Safety Phrases ]:
S45-S36/37/39-S26
[ RIDADR ]:
1325.0
[ WGK Germany ]:
3
[ RTECS ]:
GX9800000
[ Hazard Class ]:
4.1
[ HS Code ]:
2914299000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2914299000
[ Summary ]:
2914299000. other cyclanic, cyclenic or cyclotherpenic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%
Articles
J. Am. Chem. Soc. 130(23) , 7178-9, (2008)
Vinylcyclopropane (VCP) has been well applied as a five-carbon component, rather than a three-carbon component, in transition-metal catalyzed cycloadditions. Here we demonstrate a Rh(I)-catalyzed [3 +...
Total synthesis of (+/-)-asteriscanolide.J. Org. Chem. 66(22) , 7443-8, (2001)
The total synthesis of asteriscanolide (1) has been achieved by taking advantage on an intermolecular Pauson-Khand cycloaddition and a ring-closing metathesis as key bond-forming transformations. The ...
Synthesis and antimicrobial evaluation of some new cyclooctanones and cyclooctane-based heterocycles.Arch. Pharm. (Weinheim) 345(3) , 231-9, (2012)
The versatile synthon (E)-2-((dimethyl amino)methylene)cyclooctanone (2) was used as a key intermediate for the synthesis of cyclooctanones and cyclooctane-based heterocycles with pyrazole, isoxazole,...