3-Hydroxyanthranilic acid
3-Hydroxyanthranilic acid structure
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Common Name | 3-Hydroxyanthranilic acid | ||
|---|---|---|---|---|
| CAS Number | 548-93-6 | Molecular Weight | 153.135 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 356.9±37.0 °C at 760 mmHg | |
| Molecular Formula | C7H7NO3 | Melting Point | 240 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 169.6±26.5 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Increased conversion of tryptophan to nicotinamide in rats by dietary valproate.
Biosci. Biotechnol. Biochem. 77(2) , 295-300, (2013) Valproic acid (VPA) is a short-chained, branched fatty acid that is widely used in humans as an anticonvulsant and mood stabilizer, and has been reported to increase the liver NAD concentration. We investigated the effects of VPA on the conversion of tryptoph... |
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Time-dependent effects of L-tryptophan administration on urinary excretion of L-tryptophan metabolites.
J. Nutr. Sci. Vitaminol. 60(4) , 255-60, (2014) We have previously reported that dietary supplementation with up to 5.0 g/d of L-tryptophan (L-Trp) for 21 d has no adverse effects, judging from the levels of general blood variables, in healthy women. We performed a randomized, double-blind, placebo-control... |
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The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.
J. Nutr. 143(7) , 1046-51, (2013) In mammals, nicotinamide (Nam) is biosynthesized from l-tryptophan (l-Trp). The enzymes involved in the initial step of the l-Trp→Nam pathway are l-Trp-2,3-dioxygenase (TDO) and indoleamine-2,3-dioxygenase (IDO). We aimed to determine whether tdo-knockout (td... |
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Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 898 , 121-9, (2012) Highlights ► A rapid SPE/LCMS method assaying kynurenine metabolites has been developed. ► LCMS detection was performed in positive and negative electrospray ionization. ► The method had a flow rate of 0.2mL/min and a total run time of 12min. ► The assay meth... |
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3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis.
Proc. Natl. Acad. Sci. U. S. A. 104 , 18619-24, (2007) 3-Hydroxyanthranilic acid (HAA), a compound generated during tryptophan metabolism initiated by indoleamine 2,3-dioxygenase, is known to induce T cell death, but its molecular target is not known. Here we report that HAA inhibits NF-kappaB activation upon T c... |
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Behavioral Deficits Are Accompanied by Immunological and Neurochemical Changes in a Mouse Model for Neuropsychiatric Lupus (NP-SLE).
Int. J. Mol. Sci. 16 , 15150-71, (2015) Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) have been understudied compared to end-organ failure and peripheral pathology. Neuropsychiatric symptoms, particularly affective and cognitive indications, may be among the earliest manifestat... |
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Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice.
Brain. Behav. Immun. 46 , 147-53, (2015) Chronic pain frequently co-occurs with major depressive disorder but the mechanisms are poorly understood. We investigated the contribution of indoleamine 2,3-dioxygenase-1 (IDO1), a rate-limiting enzyme in the conversion of tryptophan to neurotoxic metabolit... |
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Comparison of peak-picking workflows for untargeted liquid chromatography/high-resolution mass spectrometry metabolomics data analysis.
Rapid Commun. Mass Spectrom. 29(1) , 119-27, (2014) Data analysis is a key step in mass spectrometry based untargeted metabolomics, starting with the generation of generic peak lists from raw liquid chromatography/mass spectrometry (LC/MS) data. Due to the use of various algorithms by different workflows, the ... |
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A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.
Clin. Exp. Immunol. 173(1) , 121-30, (2013) Circulating neopterin and kynurenine/tryptophan ratio (KTR) increase during inflammation and serve as markers of cellular immune activation, but data are sparse on other determinants of these markers and metabolites of the kynurenine pathway. We measured neop... |
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An exploratory study of the interplay between decreased concentration of tryptophan, accumulation of kynurenines, and inflammatory arthritis.
IUBMB Life 64(12) , 983-7, (2012) Tryptophan is an essential amino acid which influences a wide range of physiological processes, including mood, cognition, and immunity. In the autoimmune diseases, such as rheumatoid arthritis (RA), the induction of tryptophan catabolism may help to diminish... |