Aspoxicillin
Aspoxicillin structure
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Common Name | Aspoxicillin | ||
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| CAS Number | 63358-49-6 | Molecular Weight | 493.533 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 985.1±65.0 °C at 760 mmHg | |
| Molecular Formula | C21H27N5O7S | Melting Point | 195-198° (dec) | |
| MSDS | Chinese USA | Flash Point | 549.5±34.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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[In vitro study on efficacy of combination use of aspoxicillin and beta-lactam preparations (ceftazidime, cefmetazole and aztreonam) against bacteria isolated from abdominal infections].
Jpn. J. Antibiot. 45(7) , 763-73, (1992) An in vitro study was done to evaluate combination use of aspoxicillin (ASPC) with each of 3 beta-lactam preparations, ceftazidime (CAZ), cefmetazole (CMZ) and aztreonam (AZT). The results obtained are summarized as follows: 1. ASPC has strong activity agains... |
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[A clinical study of combined therapy of aspoxicillin and ceftazidime on intractable respiratory infections].
Jpn. J. Antibiot. 45(10) , 1282-94, (1992) Both aspoxicillin (ASPC) and ceftazidime (CAZ) were administered together to 55 patients with intractable respiratory tract infections. ASPC and CAZ were administered at daily doses of 4 g and 2 to 4 g, respectively. Clinical effects were excellent in 11 case... |
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Separation and determination of aspoxicillin in human plasma by micellar electrokinetic chromatography with direct sample injection.
J. Chromatogr. A. 515 , 245-55, (1990) Both the separation and determination of aspoxicillin in human plasma by micellar electrokinetic chromatography (MEKC) were investigated. Selectivity in the separation of seven penicillin antibiotics was improved by using MEKC in comparison with capillary zon... |
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Antimicrobial susceptibility of Pasteurella multocida isolated from cattle and pigs.
J. Vet. Med. B. Infect. Dis. Vet. Public Health 48(7) , 555-60, (2001) Minimum inhibitory concentrations (MICs) of 10 antimicrobial agents were determined for Pasteurella multocida from cattle and pigs (72 and 68 isolates, respectively). Higher MICs were observed with oxytetracycline, doxycycline, tilmicosin and thiamphenicol fo... |
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Activity of sub-minimal inhibitory concentrations of aspoxicillin in prolonging the postantibiotic effect against Staphylococcus aureus.
J. Antimicrob. Chemother. 26(1) , 29-38, (1990) Aspoxicillin, a newly developed acylureido-penicillin with a long half-life in mouse serum of 55 min, induced postantibiotic effects (PAEs) against Staphylococcus aureus Smith of 1.7 h in vitro and 5.2 h in vivo in a thigh infection model in neutropenic mice.... |
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Aspoxicillin versus piperacillin in severe abdominal infections--a comparative phase III study.
J. Antimicrob. Chemother. 34(5) , 813-7, (1994) We compared aspoxicillin, a new broad-spectrum penicillin derivative, with piperacillin in severe abdominal infection. Aspoxicillin 4 g administered tds (n = 52) or piperacillin 4 g qds (n = 53) usually as monotherapy were randomly given to patients suffering... |
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Determination of aspoxicillin in broncho-alveolar lavage fluid by high-performance liquid chromatography with photolysis and electrochemical detection.
J. Chromatogr. A. 615(1) , 180-5, (1993) A determination method for the penicillin antibiotic aspoxicillin in broncho-alveolar lavage fluid has been developed, involving high-performance liquid chromatography and post-column photolysis. The method enabled the determination of aspoxicillin at concent... |
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Pharmacokinetics of aspoxicillin in subjects with normal and impaired renal function.
Arzneimittelforschung 38(11) , 1635-9, (1988) The pharmacokinetics of aspoxicillin [2S,5R,6R)-6-[(2R)-2-[(2R)-2-amino-3-(methylcarbamoyl)propionam ido]-2- (p-hydroxyphenyl)acetamido]penicillanic acid) in 10 subjects with normal kidney function and in 20 patients suffering from impaired renal function wer... |
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Therapeutic effect of aspoxicillin on experimental pneumonia with Klebsiella pneumoniae in mice.
Drugs Exp. Clin. Res. 15(6-7) , 291-6, (1989) The therapeutic effects of aspoxicillin (ASPC) on an experimental pneumonia in mice were compared with those of piperacillin (PIPC) and mezlocillin (MZPC) under various administration schedules. The pneumonia was induced with K. pneumoniae B-54 by the aerosol... |
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An experimental meningitis with Streptococcus pneumoniae in rats: therapeutic effect of aspoxicillin and its penetration into CSF.
Drugs Exp. Clin. Res. 15(6-7) , 297-301, (1989) An experimental meningitis model was produced in rats with Streptococcus pneumoniae Type III and used to evaluate the therapeutic effect of aspoxicillin in comparison with piperacillin, mezlocillin and ampicillin. At the same time, their bactericidal activiti... |