Japanese Journal of Antibiotics 1992-10-01

[A clinical study of combined therapy of aspoxicillin and ceftazidime on intractable respiratory infections].

K Yamaki, R Suzuki, F Taki, K Takagi, T Satake, K Mizuno, K Baba, H Aihara, M Mori, K Yamada

Index: Jpn. J. Antibiot. 45(10) , 1282-94, (1992)

Full Text: HTML

Abstract

Both aspoxicillin (ASPC) and ceftazidime (CAZ) were administered together to 55 patients with intractable respiratory tract infections. ASPC and CAZ were administered at daily doses of 4 g and 2 to 4 g, respectively. Clinical effects were excellent in 11 cases, good in 33, fair in 7 and poor in 4, thus the efficacy rate was 80.0%. Bacteriologically, identified organisms were eradicated in 14 cases out of 21, decreased in 3, exchanged in 2 and unchanged in 2. The eradication rate was 76.2%. As a side effect, diarrhea was found in only one case, and abnormal laboratory test values were observed in 4 cases. However, these adverse reactions were not severe, therefore it was possible to continue the chemotherapy. These results indicate that the combination antimicrobial chemotherapy of ASPC and CAZ is effective against intractable respiratory tract infections.