Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Aspoxicillin
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Aspoxicillin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

63358-49-6

63358-49-6 structure

63358-49-6 structure

Name: Aspoxicillin
Chemical Name: Aspoxicillin
CAS Number: 63358-49-6
Molecular Formula: C₂₁H₂₇N₅O₇S
Molecular Weight: 493.533
Catalog: API Antibiotics Penicillin
Create Date: 2018-06-02 08:00:00
Modify Date: 2025-08-20 17:54:23
Aspoxicillin is a broad-spectrum antimicrobial agent against 68 isolates of Actinobacillus pleuropneumoniae with an MIC90 value of <= 0.05 μg/ml. Aspoxicillin has a long half-life in mouse serum of 55 minutes[1][2].

Name	Aspoxicillin
Synonyms	glycinamide,n-methyl-d-asparaginyl-n-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-a (2S,5R,6R)-6-({(2R)-2-(4-Hydroxyphenyl)-2-[(N-methyl-D-asparaginyl)amino]acetyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-[[(2R)-2-amino-4-(methylamino)-1,4-dioxobutyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)- ASPOXICILLIN 3-HYDRATE n(sup4)-methyl-d-asparagininylamoxicillin Aspoxicillin [2S-(2a,5a,6b)]-N-Methyl-D-asparaginyl-N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-D-2-(4-hydroxyphenyl)glycinamide N4-Methyl-D-asparaginylamoxicillin 6-[D-2-(D-2-Amino-3-N-methylcarbamoylpropionamido)-2-p-hydroxyphenylacetamido]penicillanic Acid Doyle Aspoxicilin (2S,5R,6R)-6-[(2R)-2-[(2R)-2-Amino-3-(methylcarbamoyl)propionamido]-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid TA 058 ASPC

Description	Aspoxicillin is a broad-spectrum antimicrobial agent against 68 isolates of Actinobacillus pleuropneumoniae with an MIC90 value of <= 0.05 μg/ml. Aspoxicillin has a long half-life in mouse serum of 55 minutes[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	microbe[1]
In Vitro	Aspoxicillin is a semisynthetic penicillin derivative[2]Aspoxicillin induces postantibiotic effects (PAEs) against Staphylococcus aureus Smith of 1.7 h in vitro[2].
In Vivo	Aspoxicillin induces PAEs against Staphylococcus aureus Smith of 5.2 h in vivo in a thigh infection model in neutropenic mice[2].
References	[1]. Yoshimura H, et al. Comparative in vitro activity of 16 antimicrobial agents against Actinobacillus pleuropneumoniae. Vet Res Commun. 2002 Jan;26(1):11-9. [2]. Oshida T, et al. Activity of sub-minimal inhibitory concentrations of aspoxicillin in prolonging the postantibiotic effect against Staphylococcus aureus. J Antimicrob Chemother. 1990 Jul;26(1):29-38.

Density	1.5±0.1 g/cm3
Boiling Point	985.1±65.0 °C at 760 mmHg
Melting Point	195-198° (dec)
Molecular Formula	C₂₁H₂₇N₅O₇S
Molecular Weight	493.533
Flash Point	549.5±34.3 °C
Exact Mass	493.163116
PSA	215.87000
LogP	-0.53
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.672
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MB7548000

CHEMICAL NAME :: Glycinamide, N-methyl-D-asparaginyl-N-(2-carboxy-3,3-dimethyl-7-ox o-4-thia-1- azabicyclo(3.2.0)hept-6-yl)-D-2-(4-hydroxyphenyl)-, (2S-(2-alpha,5-alpha,6-beta))-

CAS REGISTRY NUMBER :: 63358-49-6

LAST UPDATED :: 199109

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C21-H27-N5-O7-S

MOLECULAR WEIGHT :: 493.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,20,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,20,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,20,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,20,1990

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26
RIDADR	NONH for all modes of transport
RTECS	MB7548000

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.