Imidazo[1,2-a]pyridine
![Imidazo[1,2-a]pyridine Structure](https://image.chemsrc.com/caspic/372/274-76-0.png)
Imidazo[1,2-a]pyridine structure
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Common Name | Imidazo[1,2-a]pyridine | ||
|---|---|---|---|---|
| CAS Number | 274-76-0 | Molecular Weight | 118.136 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 103ºC (1 mmHg) | |
| Molecular Formula | C7H6N2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 113ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Conversion of pyridine to imidazo[1,2-a]pyridines by copper-catalyzed aerobic dehydrogenative cyclization with oxime esters.
Org. Lett. 15(24) , 6254-7, (2013) A rapid and environmentally friendly conversion of pyridine to imidazo[1,2-a]pyridines has been developed via copper-catalyzed aerobic dehydrogenative cyclization with ketone oxime esters. |
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One-pot three-component synthesis of 3-nitro-2-arylimidazo[1,2-a]pyridine derivatives using air as an oxidant.
Chem. Asian J. 7(9) , 2028-31, (2012)
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Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110alpha inhibitors.
Bioorg. Med. Chem. 15(1) , 403-12, (2007) 3-{1-[(4-Fluorophenyl)sulfonyl]-1H-pyrazol-3-yl}-2-methylimidazo[1,2-a]pyridine, 2a, was discovered in our chemical library as a novel p110alpha inhibitor with an IC(50) of 0.67microM, through screening in a scintillation proximity assay. Optimization of the ... |
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Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs.
Eur. J. Med. Chem. 46 , 1874, (2011) New antimicrobial agents, imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole, have been synthesized. Their antimicrobial activities were conducted against various Gram-positive, Gram-negative bacteria and fungi. Compounds 6c, 7a, 10b, 11a, 12b, 14a, ... |
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A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors.
Bioorg. Med. Chem. Lett. 16(21) , 5598-601, (2006) Utilizing modeling information from a recently resolved structure of human HIF-1alpha prolyl hydroxylase (EGLN1) and structure-based design, a novel series of imidazo[1,2-a]pyridine derivatives was prepared. The activity of these compounds was determined in a... |
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Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors
Bioorg. Med. Chem. Lett. 22(24) , 7326-9, (2012) Imidazo[1,2-a]pyridine derivatives were designed, synthesized, and evaluated as inhibitors of the apoptosis signal-regulating kinase 1 (ASK1). These were based on a benzothiazole derivative that was discovered from high-throughput screening of our compound li... |
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Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents.
Eur. J. Med. Chem. 58 , 543-56, (2012) A novel series of 2,3-diarylimidazo[1,2-a]pyridines was synthesized and evaluated for their antileishmanial activities. Four derivatives exhibited good activity against the promastigote and intracellular amastigote stages of Leishmania major, coupled with a l... |
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IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.
Bioorg. Med. Chem. Lett. 18(12) , 3656-60, (2008) Following the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2-a]pyridino-pyridines and benzimidazolo-pyridines was explored. |
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Efficient solid-phase synthesis of a library of imidazo[1,2-a]pyridine-8-carboxamides.
J. Comb. Chem. 9(2) , 267-74, (2007) A versatile method for the solid-phase synthesis of imidazo[1,2-a]pyridine-based derivatives, imidazo[1,2-a]pyridine-8-carboxamides, has been developed. They were obtained by treatment of the amino group of the polymer-bound 2-aminonicotinate with different a... |
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Functionalized heterocyclic scaffolds derived from Morita-Baylis-Hillman Acetates.
Chem. Commun. (Camb.) 49(70) , 7738-40, (2013) Five series of heterocycles with extraordinary structural diversity have been regiospecifically synthesized from the same Morita-Baylis-Hillman Acetates (MBHAs). All four potential electrophilic sites (α, β, γ, δ) of MBHAs are proved to be reactive. |