Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents.
Sophie Marhadour, Pascal Marchand, Fabrice Pagniez, Marc-Antoine Bazin, Carine Picot, Olivier Lozach, Sandrine Ruchaud, Maud Antoine, Laurent Meijer, Najma Rachidi, Patrice Le Pape
Index: Eur. J. Med. Chem. 58 , 543-56, (2012)
Full Text: HTML
Abstract
A novel series of 2,3-diarylimidazo[1,2-a]pyridines was synthesized and evaluated for their antileishmanial activities. Four derivatives exhibited good activity against the promastigote and intracellular amastigote stages of Leishmania major, coupled with a low cytotoxicity against the HeLa human cell line. The impact of compound lipophilicity on antiparasitic activities was investigated by Log D comparison. Although LmCK1 could be the parasitic target for three compounds (13, 18, 21), the inhibition of another target is under study to explain the antileishmanial effect of the most promising compounds.Copyright © 2012 Elsevier Masson SAS. All rights reserved.
Related Compounds
| Structure | Name/CAS No. | Molecular Formula | Articles |
|---|---|---|---|
![Imidazo[1,2-a]pyridine Structure](https://image.chemsrc.com/caspic/372/274-76-0.png) |
Imidazo[1,2-a]pyridine
CAS:274-76-0 |
C7H6N2 |
|
Conversion of pyridine to imidazo[1,2-a]pyridines by copper-...
2013-12-20 [Org. Lett. 15(24) , 6254-7, (2013)] |
|
One-pot three-component synthesis of 3-nitro-2-arylimidazo[1...
2012-09-01 [Chem. Asian J. 7(9) , 2028-31, (2012)] |
|
Synthesis and biological evaluation of imidazo[1,2-a]pyridin...
2007-01-01 [Bioorg. Med. Chem. 15(1) , 403-12, (2007)] |
|
Design, synthesis and in vitro antimicrobial evaluation of n...
2011-05-01 [Eur. J. Med. Chem. 46 , 1874, (2011)] |
|
A novel series of imidazo[1,2-a]pyridine derivatives as HIF-...
2006-11-01 [Bioorg. Med. Chem. Lett. 16(21) , 5598-601, (2006)] |