Bioorganic & Medicinal Chemistry Letters 2008-06-15

IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.

George M Buckley, Richard Fosbeary, Joanne L Fraser, Lewis Gowers, Alicia P Higueruelo, Lynwen A James, Kerry Jenkins, Stephen R Mack, Trevor Morgan, David M Parry, William R Pitt, Oliver Rausch, Marianna D Richard, Verity Sabin

Index: Bioorg. Med. Chem. Lett. 18(12) , 3656-60, (2008)

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Abstract

Following the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2-a]pyridino-pyridines and benzimidazolo-pyridines was explored.