7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2-oxo-2H-1,4-benzodiazepin-3-yl acetate
7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2-oxo-2H-1,4-benzodiazepin-3-yl acetate structure
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Common Name | 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2-oxo-2H-1,4-benzodiazepin-3-yl acetate | ||
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| CAS Number | 2848-96-6 | Molecular Weight | 363.19500 | |
| Density | 1.45 g/cm3 | Boiling Point | 524.4ºC at 760 mmHg | |
| Molecular Formula | C17H12Cl2N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 270.9ºC | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Stereoselective binding of 3-acetoxy-, and 3-hydroxy-1,4-benzodiazepine-2-ones to human serum albumin. Selective allosteric interaction with warfarin enantiomers.
Biochem. Pharmacol. 35(2) , 263-9, (1986) Stereoselective binding of oxazepam, lorazepam, temazepam and methyl lorazepam as well as of their acetates to human serum albumin was investigated by different techniques. The 2'-chlorine and the N(1)-methyl substitution exert opposite effects on the antipod... |
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Stereoselective kinetics of warfarin binding to human serum albumin: effect of an allosteric interaction.
Chirality 14(5) , 442-8, (2002) Kinetic and equilibrium binding studies were performed on the interaction of warfarin enantiomers with human serum albumin (HSA) in the absence and presence of lorazepam acetate (LoAc) enantiomers. Binding kinetics were followed by recording changes in the fl... |
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Stereoselective allosteric binding interaction on human serum albumin between ibuprofen and lorazepam acetate.
Chirality 11(2) , 115-20, (1999) The effect of ibuprofen enantiomers on the stereoselective binding of 3-acyloxy-1,4-benzodiazepines to human serum albumin (HSA) was studied using both native and Sepharose-immobilized protein. (S)-Lorazepam acetate exhibited considerably enhanced binding, es... |
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Enantioselective hydrolysis of lorazepam 3-acetate by esterases in human and rat liver microsomes and rat brain S9 fraction.
Drug Metab. Dispos. 19(3) , 609-13, (1991) Rates of hydrolysis of racemic and enantiomeric lorazepam 3-acetates (LZA) by esterases in human and rat liver microsomes and rat brain S9 fraction were compared. LZA and its hydrolysis product were analyzed by chiral stationary phase HPLC. When rac-LZA was t... |
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Recurrent complex partial status epilepticus associated with tiagabine rechallenge.
Acta Neurol. Belg. 102(1) , 19-20, (2002)
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Application of ultrafiltration and CD spectroscopy for studying stereoselective binding of racemic ligands.
Biochem. Biophys. Res. Commun. 109(3) , 851-7, (1982)
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Stationary ultrafiltration: a radio-tracer technique for studying stereoselective binding of racemic ligands.
Biochem. Biophys. Res. Commun. 97(1) , 1-7, (1980) The continuous exchange of the radioactive free ligand by its non-labelled isotopomer of identical concentration does not affect the position of the overall-equilibrium. The replacement of the enantiomer of higher binding affinity lags behind the replacement ... |