Disodium protoporphyrin IX
Disodium protoporphyrin IX structure
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Common Name | Disodium protoporphyrin IX | ||
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| CAS Number | 50865-01-5 | Molecular Weight | 606.622 | |
| Density | N/A | Boiling Point | 1128.9ºC at 760 mmHg | |
| Molecular Formula | C34H32N4Na2O4 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 636.6ºC | |
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Protein structure. Structure and activity of tryptophan-rich TSPO proteins.
Science 347(6221) , 551-5, (2015) Translocator proteins (TSPOs) bind steroids and porphyrins, and they are implicated in many human diseases, for which they serve as biomarkers and therapeutic targets. TSPOs have tryptophan-rich sequences that are highly conserved from bacteria to mammals. He... |
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Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy.
Nat. Med. 19(4) , 418-20, (2013) Co-therapy with rifampicin (RIF) and isoniazid (INH) used to treat tuberculosis in humans frequently causes liver injury. Here, using a pregnane X receptor (PXR)-humanized mouse model, we found that co-treatment with RIF and INH causes accumulation of the end... |
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Salicylic acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity.
Mol. Pharmacol. 84(6) , 824-33, (2013) Salicylic acid is a classic nonsteroidal anti-inflammatory drug. Although salicylic acid also induces mitochondrial injury, the mechanism of its antimitochondrial activity is not well understood. In this study, by using a one-step affinity purification scheme... |
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Effects of 5-aminolevulinic acid-mediated photodynamic therapy on antibiotic-resistant staphylococcal biofilm: an in vitro study.
J. Surg. Res. 184(2) , 1013-21, (2013) Treatments of infections are not always successful because of multi-antibiotic-resistant organisms. It is therefore particularly urgent to provide more effective anti-infective strategy against these organisms. 5-Aminolevulinic acid (ALA), with the chemical s... |
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Measurement of the base number of DNA using a special calliper made of a split G-quadruplex.
Chem. Commun. (Camb.) 48(98) , 11990-2, (2012) A special DNA calliper made of a split G-quadruplex was constructed to measure the length of DNA in a single-digit base number range between two selected sequences. The enhanced fluorescence of PPIX changed with the distance between two G-rich segments. |
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One divinyl reductase reduces the 8-vinyl groups in various intermediates of chlorophyll biosynthesis in a given higher plant species, but the isozyme differs between species.
Plant Physiol. 161(1) , 521-34, (2013) Divinyl reductase (DVR) converts 8-vinyl groups on various chlorophyll intermediates to ethyl groups, which is indispensable for chlorophyll biosynthesis. To date, five DVR activities have been detected, but adequate evidence of enzymatic assays using purifie... |
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Electrospray ionization on porous spraying tips for direct sample analysis by mass spectrometry: enhanced detection sensitivity and selectivity using hydrophobic/hydrophilic materials as spraying tips.
Rapid Commun. Mass Spectrom. 27(6) , 713-21, (2013) Despite various porous materials having been widely adopted as spraying tips for direct sample analysis using electrospray ionization mass spectrometry (ESI-MS), the effect of surface property and porosity of spraying tip materials on their analytical perform... |
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In vitro comparison of hypericin and 5-aminolevulinic acid-derived protoporphyrin IX for photodynamic inactivation of medulloblastoma cells.
PLoS ONE 7(12) , e51974, (2012) Hypericin (HYP) is a naturally occurring photosensitizer. Cellular uptake and photodynamic inactivation after incubation with this photosensitizer have neither been examined in medulloblastoma cells in vitro, nor compared with 5-aminolevulinic acid-derived pr... |
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A conserved amphipathic ligand binding region influences k-path-dependent activity of cytochrome C oxidase.
Biochemistry 52(8) , 1385-96, (2013) A conserved, crystallographically defined bile acid binding site was originally identified in the membrane domain of mammalian and bacterial cytochrome c oxidase (CcO). Current studies show other amphipathic molecules including detergents, fatty acids, steroi... |
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Factors implicated in the assessment of aminolevulinic acid-induced protoporphyrin IX fluorescence.
Biochim. Biophys. Acta 1830(3) , 2750-62, (2013) Photodynamic therapy and photodiagnosis of cancer requires preferential accumulation of fluorescent photosensitizers in tumors. Clinical evidence documents feasibility of ALA-based photodiagnosis for tumor detection. However, false positive results and large ... |