17α-hydroxyprogesterone
17α-hydroxyprogesterone structure
|
Common Name | 17α-hydroxyprogesterone | ||
|---|---|---|---|---|
| CAS Number | 68-96-2 | Molecular Weight | 330.461 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 482.9±45.0 °C at 760 mmHg | |
| Molecular Formula | C21H30O3 | Melting Point | 276°C | |
| MSDS | Chinese USA | Flash Point | 260.0±25.2 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin.
J. Med. Chem. 51 , 2047-56, (2008) A benchmark data set of steroids with known affinity for sex hormone-binding globulin (SHBG) has been widely used to validate popular molecular field-based QSAR techniques. We have expanded the data set by adding a number of nonsteroidal SHBG ligands identifi... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Bioorg. Med. Chem. 15 , 6943-55, (2007) A set of 116 structurally very diverse compounds, mainly drugs, was characterized by 1630 molecular descriptors. The biological property modelled in this study was the transdermal permeability coefficient logK(p). The main objective was to find a limited set ... |
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Androgen synthesis in the gonadotropin-suppressed human testes can be markedly suppressed by ketoconazole.
J. Clin. Endocrinol. Metab. 98(3) , 1198-206, (2013) The concentration of intratesticular testosterone (IT-T) required for human spermatogenesis is unknown because spermatogenesis can persist despite the markedly reduced IT-T concentrations observed with LH suppression. Methods to lower IT-T further are needed ... |
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Metabolism of the polycyclic musk galaxolide and its interference with endogenous and xenobiotic metabolizing enzymes in the European sea bass (Dicentrarchus labrax).
Environ. Pollut. 174 , 214-21, (2013) This study investigates the metabolism and mode of action of galaxolide (HHCB) in the European sea bass -Dicentrarchus labrax- following a single intraperitoneal injection of 50 mg HHCB/kg body weight. In addition, a group of fish was injected with 50 mg/kg o... |
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Influence of different length spacers containing enzyme conjugate on functional parameters of progesterone ELISA.
J. Immunoassay Immunochem. 34(1) , 94-108, (2013) In steroid enzyme immunoassay (EIA), there is an increase or decrease of labeled steroid recognition by antibody due to homologous and heterologous combinations of enzyme conjugate with immunogen that affects sensitivity of the assay. We have introduced three... |
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Rapid diagnosis of phenylketonuria and other aminoacidemias by quantitative analysis of amino acids in neonatal blood spots by gas chromatography-mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 775(1) , 115-20, (2002) A new method for quantifying specific amino acids in small volumes of plasma and whole blood has been developed. Volatile derivatives of amino acids are analyzed by gas chromatography-mass spectrometry. The method only takes a few minutes to perform and requi... |
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The occurrence of gamma-glutamylphenylalanine in the urine of newborn phenylketonurics.
Clin. Chim. Acta 94(3) , 237-40, (1979) The urine of untreated phenylketonurics in the first weeks of life contains gamma-glutamylphenylalanine (0.07--0.69 mmol/g creatinine, 12 samples) visible on the normal 2-dimensional electrophoreto-chromatogram. This compound is less prominent or absent when ... |
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Renal transport of aromatic acids in patients with phenylketonuria.
J. Inherit. Metab. Dis. 4(2) , 69-70, (1981) Renal clearance of phenylpyruvic acid is maximal at a plasma concentration of 40-60 mumol/l. This concentration is obtained with plasma phenylalanine concentrations of 1.0-1.2 mmol/l, the threshold for separating classical phenylketonuria from phenylketonuria... |