17α-hydroxyprogesterone

Modify Date: 2024-01-02 07:01:13

17α-hydroxyprogesterone Structure
17α-hydroxyprogesterone structure
Common Name 17α-hydroxyprogesterone
CAS Number 68-96-2 Molecular Weight 330.461
Density 1.2±0.1 g/cm3 Boiling Point 482.9±45.0 °C at 760 mmHg
Molecular Formula C21H30O3 Melting Point 276°C
MSDS Chinese USA Flash Point 260.0±25.2 °C
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger

 Names

Name 17α-hydroxyprogesterone
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 482.9±45.0 °C at 760 mmHg
Melting Point 276°C
Molecular Formula C21H30O3
Molecular Weight 330.461
Flash Point 260.0±25.2 °C
Exact Mass 330.219482
PSA 54.37000
LogP 2.89
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.560
Storage condition -20?C Freezer

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU5060000
CHEMICAL NAME :
Pregn-4-ene-3,20-dione, 17-hydroxy-
CAS REGISTRY NUMBER :
68-96-2
BEILSTEIN REFERENCE NO. :
2062088
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C21-H30-O3
MOLECULAR WEIGHT :
330.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
65 mg/kg
SEX/DURATION :
female 8-32 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - gastrointestinal system Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948- Volume(issue)/page/year: 26,151,1960
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
5 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 28,18,1956

 Safety Information

Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger
Hazard Statements H225-H301 + H311 + H331-H370
Precautionary Statements P210-P260-P280-P301 + P310-P311
Personal Protective Equipment Eyeshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T: Toxic;
Risk Phrases 61
Safety Phrases S53-S22-S36/37/39-S45
RIDADR 2811.0
WGK Germany 3
RTECS TU5060000

 Synthetic Route

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 Synonyms

17α-Hydroxypregn-4-ene-3,20-dione
17-Hydroxypregn-4-en-3,20-dione
MFCD00003659
hydroxyprogesteronum [INN_la]
17-Hydroxypregn-4-ene-3,20-dione
4-Pregnen-17a-ol-3,20-dione
4-Pregnen-17α-ol-3,20-dione
17alpha-hydroxyprogesterone
Pregn-4-ene-3,20-dione, 17-hydroxy-
17α-Hydroxyprogesterone
Gestageno
L E5 B666 OV MUTJ A1 E1 FV1 FQ &&17α
EINECS 200-699-4
17a-Hydroxypregn-4-ene-3,20-dione
17A-hydroxyprogesterone
17-Hydroxyprogesterone
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