hydroxyprogesterone caproate

Modify Date: 2024-01-03 03:52:55

hydroxyprogesterone caproate structure	Common Name	hydroxyprogesterone caproate
	CAS Number	630-56-8	Molecular Weight	428.604
	Density	1.1±0.1 g/cm3	Boiling Point	540.0±50.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₄₀O₄	Melting Point	119°C
	MSDS	N/A	Flash Point	229.2±30.2 °C
	Symbol	GHS08	Signal Word	Danger

Use of hydroxyprogesterone caproate

Hydroxyprogesterone caproate is a synthetic, steroidal progestin; an ester derivative of 17α-hydroxyprogesterone formed from caproic acid.

Name	17α-Caproyloxyprogesterone
Synonym	More Synonyms

Description	Hydroxyprogesterone caproate is a synthetic, steroidal progestin; an ester derivative of 17α-hydroxyprogesterone formed from caproic acid.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. Armstrong J. Unintended consequences--the cost of preventing preterm births after FDA approval of a branded version of 17OHP. N Engl J Med. 2011 May 5;364(18):1689-91. [2]. Hauth JC, et al. The effect of 17 alpha-hydroxyprogesterone caproate on pregnancy outcome in an active-duty military population. Am J Obstet Gynecol. 1983 May 15;146(2):187-90.

Description

Hydroxyprogesterone caproate is a synthetic, steroidal progestin; an ester derivative of 17α-hydroxyprogesterone formed from caproic acid.

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Others

References

[1]. Armstrong J. Unintended consequences--the cost of preventing preterm births after FDA approval of a branded version of 17OHP. N Engl J Med. 2011 May 5;364(18):1689-91.

[2]. Hauth JC, et al. The effect of 17 alpha-hydroxyprogesterone caproate on pregnancy outcome in an active-duty military population. Am J Obstet Gynecol. 1983 May 15;146(2):187-90.

Density	1.1±0.1 g/cm3
Boiling Point	540.0±50.0 °C at 760 mmHg
Melting Point	119°C
Molecular Formula	C₂₇H₄₀O₄
Molecular Weight	428.604
Flash Point	229.2±30.2 °C
Exact Mass	428.292664
PSA	60.44000
LogP	5.53
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.532
Storage condition	2~8℃

hydroxyprogesterone caproate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5085000

CHEMICAL NAME :: Pregn-4-ene-3,20-dione, 17-hydroxy-, hexanoate

CAS REGISTRY NUMBER :: 630-56-8

LAST UPDATED :: 199706

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C27-H40-O4

MOLECULAR WEIGHT :: 428.67

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A1 E1 FV1 FOV5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 12 mg/kg

SEX/DURATION :: female 6-20 week(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 211,1171,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 700 mg/kg

SEX/DURATION :: female 18-24 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 31,48A,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 30 mg/kg

SEX/DURATION :: male 20 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 18,1225,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 61953 ug/kg

SEX/DURATION :: male 26 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 18,1225,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 45157 ug/kg

SEX/DURATION :: male 17 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 18,1225,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 4160 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 28,201,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 650 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 35,28A,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 180 mg/kg

SEX/DURATION :: female 3-21 week(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 35,129,1987 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 21,399,1979 TOXICOLOGY REVIEW TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 21,225,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6069 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 628 (estimated) No. of Female Employees: 314 (estimated)

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H360
Precautionary Statements	P201-P280-P308 + P313
Hazard Codes	T: Toxic;
Risk Phrases	R61
Safety Phrases	S53-S22-S36/37/39-S45
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TU5085000

Precursor 0
DownStream 1
CAS#:1096-38-4 16-Dehydroproge...

Progesterone, 17-hydroxy-, hexanoate

[(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] hexanoate

17-Hydroxypregn-4-ene-3,20-dione hexanoate

3,20-Dioxopregn-4-en-1-yl hexanoate

hydroxyprogesterone caproate

EINECS 211-138-8

17α-Caproyloxypregn-4-ene-3,20-dione

17-((1-Oxohexyl)oxy)pregn-4-ene-3,20-dione

Proluton depot

17-α-Hydroxyprogesterone hexanoate

17α-Hydroxyprogesterone hexanoate

Delalutin

3,20-Dioxopregn-4-en-17-ylhexanoat

Gesterol LA 250

Pregn-4-ene-3,20-dione, 17-((1-oxohexyl)oxy)-

Pharlon

Hexanoic acid, 3,20-dioxopregn-4-en-1-yl ester

Pregn-4-ene-3,20-dione, 17-hydroxy-, hexanoate

(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl hexanoate

17-α-Hexanoyloxypregn-4-ene-3,20-dione

17-α-hydroxy-progesterone caproate

MFCD00072134

Pregn-4-ene-3,20-dione, 17-[(1-oxohexyl)oxy]-

17-α-Hydroxyprogesterone caproate

Teralutil

17a-Hydroxyprogesterone caproate

Hexanoic acid, 3,20-dioxopregn-4-en-17-yl ester

17a-Hydroxyprogesterone Hexanoate

17α-Hydroxyprogesterone caproate

Proge

3,20-Dioxopregn-4-en-17-yl hexanoate

17-[(1-Oxohexyl)oxy]pregn-4-ene-3,20-dione

DC Chemicals Limited
China
Product Name: Hydroxyprogesterone caproate
Price: $100.0/100mg $200.0/250mg $400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Hydroxyprogesterone caproate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Hydroxyprogesterone Caproate
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: HYDROXIPROGESTRONE CAPROATE - 50KG
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: $66/10mM*1mLinDMSO

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hydroxyprogesterone caproate

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