ACRIFLAVINE
ACRIFLAVINE structure
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Common Name | ACRIFLAVINE | ||
|---|---|---|---|---|
| CAS Number | 8048-52-0 | Molecular Weight | 259.73 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H14ClN3 | Melting Point | 179-181 °C | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Bilobalide attenuates hypoxia induced oxidative stress, inflammation, and mitochondrial dysfunctions in 3T3-L1 adipocytes via its antioxidant potential.
Free Radic. Res. 48(10) , 1206-17, (2014) Excessive expansion of white adipose tissue leads to hypoxia which is considered as a key factor responsible for adipose tissue dysfunction in obesity. Hypoxia induces inflammation, insulin resistance, and other obesity related complications. So the hypoxia-s... |
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Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes.
Proc. Natl. Acad. Sci. U. S. A. 112 , 9112-7, (2015) Kinetoplastid parasites cause lethal diseases in humans and animals. The kinetoplast itself contains the mitochondrial genome, comprising a huge, complex DNA network that is also an important drug target. Isometamidium, for example, is a key veterinary drug t... |
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The efflux pump inhibitor timcodar improves the potency of antimycobacterial agents.
Antimicrob. Agents Chemother. 59(3) , 1534-41, (2015) Previous studies indicated that inhibition of efflux pumps augments tuberculosis therapy. In this study, we used timcodar (formerly VX-853) to determine if this efflux pump inhibitor could increase the potency of antituberculosis (anti-TB) drugs against Mycob... |
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Comparative analysis of the susceptibility to triclosan and three other biocides of avian Salmonella enterica isolates collected 1979 through 1994 and 2004 through 2010.
J. Food Prot. 76(4) , 653-6, (2013) Few studies have been conducted on changes in the susceptibility of bacteria due to long-term use of biocides. A total of 375 avian Salmonella isolates collected in Germany from healthy or diseased animals during two time periods, 1979 through 1994 and 2004 t... |
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The Hedgehog receptor patched functions in multidrug transport and chemotherapy resistance.
Mol. Cancer Res. 10(11) , 1496-508, (2012) Most anticancer drugs fail to eradicate tumors, leading to the development of drug resistance and disease recurrence. The Hedgehog signaling plays a crucial role during embryonic development, but is also involved in cancer development, progression, and metast... |
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Cytotoxic effect of acriflavine against clinical isolates of Acanthamoeba spp.
Parasitol. Res. 112(2) , 529-33, (2013) Acanthamoeba keratitis (AK) is a potentially devastating and sight-threatening infection of the cornea caused by the ubiquitous free-living amoebae, Acanthamoeba species. Its eradication is difficult because the amoebas encyst, making it highly resistant to a... |
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Evaluating the effectiveness of different treatments of uterine infections in female camels (Camelus dromedarius).
Theriogenology 74(1) , 40-4, (2010) A total of 480 female camels with a history of conception failure were examined through transrectal palpation, ultrasonography, and vaginal exploration. Animals were categorized according to parity (nulliparous n=200 vs. multiparous n=280), and type of uterin... |
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Characterization of Erysipelothrix rhusiopathiae strains isolated from recent swine erysipelas outbreaks in Japan.
J. Vet. Med. Sci. 74(7) , 949-53, (2012) The objective of the present study was to characterize Erysipelothrix sp. strains from recent erysipelas outbreaks in Japan. Eighty-three (100%) strains were identified as E. rhusiopathiae, based on serotyping and spaA PCR. Fifty (60.3%), 5 (6.0%), and 28 (33... |
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Effect of frameshift mutagen acriflavine on control of resistance genes in Acinetobacter baumannii.
J. Med. Microbiol. 60(Pt 2) , 211-5, (2011) Acinetobacter baumannii is a Gram-negative pathogenic bacterium that often exhibits a multidrug-resistant phenotype causing infections at various sites of the body and increasingly leading to septicaemic shock. This study evaluated the role of acriflavine, a ... |
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Plasmid encoded AcrAB-TolC tripartite multidrug-efflux system in Acidiphilium symbioticum H8.
Curr. Microbiol. 61(3) , 163-8, (2010) Acidophilic bacterium, Acidiphilium symbioticum H8, is resistant to high levels of several heavy metals, hydrophobic agents, and organic solvents. The approximately 9.6 kb plasmid pASH8, was purified, digested with HindIII, and sub-cloned in pUC19 at the resp... |