ACRIFLAVINE

Modify Date: 2025-08-21 18:06:43

ACRIFLAVINE structure	Common Name	ACRIFLAVINE
	CAS Number	8048-52-0	Molecular Weight	259.73
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₄ClN₃	Melting Point	179-181 °C
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of ACRIFLAVINE

Acriflavine is a fluorescent dye for labeling high molecular weight RNA. It is also a topical antiseptic.

Name	acriflavine
Synonym	More Synonyms

Description	Acriflavine is a fluorescent dye for labeling high molecular weight RNA. It is also a topical antiseptic.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Research Areas >> Cancer Dye Reagents Research Areas >> Infection
In Vitro	Acriflavine is identified as a potent inhibitor of the MCT4 that can inhibit the binding between Basigin and MCT4. Acriflavine significantly inhibits growth and self-renewal potential of several glioblastoma neurosphere lines[1]. The HIF-1 inhibitor acriflavine decreases survival and growth of CML cells. It targets stem cell potential of CML cells[2].
In Vivo	Acriflavine treatment inhibits intratumoral expression of VEGF and tumor vascularization[1]. In a murine CML model, acriflavine decreases leukemia development and reduces LSC maintenance[2]. Acriflavine retards tumor growth in a murine model of breast cancer. The combination of sunitinib with acriflavine significantly decreases vascular endothelial growth factor and TGF-β expression and reduces tumor vasculature followed by increased intratumor necrosis and apoptosis[3].
Animal Admin	Mice: CML mice are treated daily with acriflavine (8 mg/kg) or PBS via intraperitoneal injection, for 10 days starting from day 7 after bone marrow transplantation[2].
References	[1]. Voss DM, et al. Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression. Sci Rep. 2017 Jun 27;7(1):4292. [2]. Cheloni G, et al. Targeting chronic myeloid leukemia stem cells with the hypoxia-inducible factor inhibitor acriflavine. Blood. 2017 Jun 2. pii: blood-2016-10-745588. [3]. Yin T, et al. HIF-1 Dimerization Inhibitor Acriflavine Enhances Antitumor Activity of Sunitinib in Breast Cancer Model. Oncol Res. 2014;22(3):139-45.

Melting Point	179-181 °C
Molecular Formula	C₁₄H₁₄ClN₃
Molecular Weight	259.73
PSA	120.85000
LogP	3.86310

ACRIFLAVINE MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR9660000

CHEMICAL NAME :: Acridinium, 3,6-diamino-10-methyl-, chloride mixed with 3,6-acridinediamine

CAS REGISTRY NUMBER :: 8048-52-0

LAST UPDATED :: 199706

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C14-H14-N3.Cl.C13-H11-N3

MOLECULAR WEIGHT :: 469.03

WISWESSER LINE NOTATION :: T C666 BKJ B1 EZ MZ &G &T C666 BNJ EZ MZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 160 mg/kg/60W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: Dominant lethal test

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Kidney

DOSE/DURATION :: 25 mg/L

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 19,55,1981 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 13,31,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 13,31,1977 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1531 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 40 (estimated) No. of Female Employees: 10 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;N:Dangerousfortheenvironment;
Risk Phrases	R22;R37/38;R41;R50/53
Safety Phrases	S26-S39-S60-S61
RIDADR	UN 3077 9/PG 3
WGK Germany	3
RTECS	AR9660000
HS Code	38249064

HS Code	38249064

Bilobalide attenuates hypoxia induced oxidative stress, inflammation, and mitochondrial dysfunctions in 3T3-L1 adipocytes via its antioxidant potential.

Free Radic. Res. 48(10) , 1206-17, (2014)

Excessive expansion of white adipose tissue leads to hypoxia which is considered as a key factor responsible for adipose tissue dysfunction in obesity. Hypoxia induces inflammation, insulin resistance...

Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes.

Proc. Natl. Acad. Sci. U. S. A. 112 , 9112-7, (2015)

Kinetoplastid parasites cause lethal diseases in humans and animals. The kinetoplast itself contains the mitochondrial genome, comprising a huge, complex DNA network that is also an important drug tar...

The efflux pump inhibitor timcodar improves the potency of antimycobacterial agents.

Antimicrob. Agents Chemother. 59(3) , 1534-41, (2015)

Previous studies indicated that inhibition of efflux pumps augments tuberculosis therapy. In this study, we used timcodar (formerly VX-853) to determine if this efflux pump inhibitor could increase th...

ACRIFLAVINE

EUFLAVINE

3,6-Diamino-10-methylacridinium chloride - 3,6-acridinediamine (1:1:1)

3,6-Diamino-10-methylacridinium Chloride mixt with 3,6-Acridine Diamine

3,6-Diamino-10-methylacridinium chloride 3,6-acridinediamine (1:1:1)

diacrid

3,6-Diamino-10-methylacridinium chloride 3,6-acridinediamine (1:1)

flavipin

Trypaflavine

Acridinium, 3,6-diamino-10-methyl-, chloride, mixt. with 3,6-acridinediamine

gonacin

3,6-Diamino-10-methylacridinium chloride - acridine-3,6-diamine (1:1:1)

flavine

Neutroflavine

EUFLAVIN

angiflan

Neutral Acriflavine

flavisept

isravin

MFCD00064307

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ACRIFLAVINE
Price: Check
Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: ACRIFLAVINE
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DC Chemicals Limited
China
Product Name: Acriflavine
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g ￥220.0/10ml
Purity: 98.0%
Delivery: 10 Day
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Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Acriflavine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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ACRIFLAVINE

Use of ACRIFLAVINE

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ACRIFLAVINE Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

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Articles41

Synonyms

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