N-Succinimidyl 6-maleimidohexanoate
N-Succinimidyl 6-maleimidohexanoate structure
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Common Name | N-Succinimidyl 6-maleimidohexanoate | ||
|---|---|---|---|---|
| CAS Number | 55750-63-5 | Molecular Weight | 308.287 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 480.6±47.0 °C at 760 mmHg | |
| Molecular Formula | C14H16N2O6 | Melting Point | 70-73 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 244.5±29.3 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Function of the Histone-Like Protein H-NS in Motility of Escherichia coli: Multiple Regulatory Roles Rather than Direct Action at the Flagellar Motor.
J. Bacteriol. 197 , 3110-20, (2015) A number of investigations of Escherichia coli have suggested that the DNA-binding protein H-NS, in addition to its well-known functions in chromosome organization and gene regulation, interacts directly with the flagellar motor to modulate its function. Here... |
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Successful acquisition of a neutralizing monoclonal antibody against a novel neutrophil-activating peptide, mitocryptide-1.
Biochem. Biophys. Res. Commun. 463 , 54-9, (2015) Mitocryptide-1 (MCT-1) is a novel neutrophil-activating peptide derived from mitochondrial cytochrome c oxidase subunit VIII, and its physiological role and involvement in various diseases have not yet been elucidated. Generating neutralizing antibodies again... |
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Moderate PEGylation of the carrier protein improves the polysaccharide-specific immunogenicity of meningococcal group A polysaccharide conjugate vaccine.
Vaccine 33 , 3208-14, (2015) Neisseria meningitidis can cause severe and fulminant diseases such as meningitis. Meningococcal capsular polysaccharide (PS) is a key virulence determinant that is not able to induce immunological memory. Conjugation of PS to a carrier protein can significan... |
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Use of maleimide-thiol coupling chemistry for efficient syntheses of oligonucleotide-enzyme conjugate hybridization probes.
Bioconjug. Chem. 1 , 71-76, (1990) Two general methods which exploit the reactivity of sulfhydryl groups toward maleimides are described for the synthesis of oligonucleotide-enzyme conjugates for use as nonradioisotopic hybridization probes. In the first approach, 6-maleimidohexanoic acid succ... |
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Design and synthesis of a peptide-PEG transporter tool for carrying adenovirus vector into cells.
Bioorg. Med. Chem. Lett. 15 , 621-624, (2005) The adenovirus vector is a promising carrier for the efficient transfer of genes into cells via the coxackie-adenovirus receptor (CAR) and integrins (alphavbeta3 and alphavbeta5). The clinical use of the adenovirus vector remains problematic however. Successf... |
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Studies on heterobifunctional cross-linking reagents, 6-maleimidohexanoic acid active esters.
Chem. Pharm. Bull. 55 , 685-687, (2007) 6-maleimidohexanoic acid N-hydroxysuccinimide ester has been used widely for preparation of enzyme immunoconjugates as a unique heterobifunctional cross-linking reagent. Its heterobifunctional reactivity is good, but its ester portion hydrolyzes easily in the... |
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Antigen-specific, IgE-selective unresponsiveness induced by antigen-liposome conjugates. Comparison of four different conjugation methods for the coupling of antigen to liposome.
Int. Arch. Allergy Immunol. 120(3) , 199-208, (1999) We have previously reported that ovalbumin (OVA) coupled with liposome via glutaraldehyde (GA) induced OVA-specific- and IgE-selective unresponsiveness in mice.In this study, OVA-liposome conjugates were made using four different coupling protocols: via GA, N... |
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Functional diversity of endothelin pathways in human lung fibroblasts may be based on structural diversity of the endothelin receptors.
Biochemistry 42(47) , 13909-18, (2003) Posttranslational modifications of the endothelin receptors A and B from human lung fibroblasts were investigated before and after stimulation of the cells with (dA)(30)-5'-S-EMC-endothelin-1. The patterns of phosphorylation and palmitoylation of both recepto... |
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Simultaneous multiple synthesis of peptide-carrier conjugates.
J. Immunol. Methods 146(1) , 83-90, (1992) Recently, the multipin approach for simultaneous multiple peptide synthesis was applied to the analysis of T cell determinants by using a novel cleavage method (Maeji et al., 1990). A diketopiperazine forming linker allowed cleavage of peptides into aqueous b... |
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More useful maleimide compounds for the conjugation of Fab' to horseradish peroxidase through thiol groups in the hinge.
J. Appl. Biochem. 6 , 56-63, (1984) Nine different maleimide compounds were evaluated for the conjugation of Fab' to horseradish peroxidase through thiol groups in the hinge. The compounds evaluated were succinimidyl maleimidoacetate (I), succinimidyl 4-maleimidobutyrate (II), succinimidyl 6-ma... |