NQTrp
NQTrp structure
|
Common Name | NQTrp | ||
|---|---|---|---|---|
| CAS Number | 185351-19-3 | Molecular Weight | 360.36300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H16N2O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Combined experimental and simulation studies suggest a revised mode of action of the anti-Alzheimer disease drug NQ-Trp.
Chemistry 21 , 12657-66, (2015) Inhibition of the aggregation of the monomeric peptide β-amyloid (Aβ) into oligomers is a widely studied therapeutic approach in Alzheimer's disease (AD). Many small molecules have been reported to work in this way, including 1,4-naphthoquinon-2-yl-L-tryptoph... |
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Naphthoquinone-Tryptophan Hybrid Inhibits Aggregation of the Tau-Derived Peptide PHF6 and Reduces Neurotoxicity.
J. Alzheimers Dis. 51 , 165-78, (2016) Tauopathies, such as Alzheimer's disease (AD), are a group of disorders characterized neuropathologically by intracellular toxic accumulations of abnormal protein aggregates formed by misfolding of the microtubule-associated protein tau. Since protein self-as... |
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