185351-19-3
185351-19-3 structure
- Name: NQTrp
- Chemical Name: (2S)-2-[(1,4-dioxonaphthalen-2-yl)amino]-3-(1H-indol-3-yl)propanoic acid
- CAS Number: 185351-19-3
- Molecular Formula: C21H16N2O4
- Molecular Weight: 360.36300
- Catalog: Research Areas Neurological Disease
- Create Date: 2017-07-31 13:25:39
- Modify Date: 2025-08-25 11:11:31
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NQTrp, an aromatic naphthoquinone-tryptophan hybrid molecule, an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. NQTrp inhibits the in vitro aggregation of hexapeptide (41GCWMLY46 within the N-terminus of γD-crystallin) as well as full-length γD-crystallin[1].
| Name | (2S)-2-[(1,4-dioxonaphthalen-2-yl)amino]-3-(1H-indol-3-yl)propanoic acid |
|---|---|
| Synonyms |
L-Tryptophan,N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)
TRY001 |
| Description | NQTrp, an aromatic naphthoquinone-tryptophan hybrid molecule, an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. NQTrp inhibits the in vitro aggregation of hexapeptide (41GCWMLY46 within the N-terminus of γD-crystallin) as well as full-length γD-crystallin[1]. |
|---|---|
| Related Catalog | |
| In Vitro | In TEM analysis, GDC6 peptide fibrils (50 μM) in the presence of NQTrp 5:1, 1:1, 1:5 ratio (GDC6: NQTrp). NQTrp effectively inhibits the fibrillation of the GDC6 peptide (50 μM) in a dose-dependent manner and prevents the formation of elongated amyloid fibrils[1]. NQTrp has no toxic effect toward retinal cell culture and reduces the cytotoxicity induced by aggregates of the hexapeptide(IC50=70 μM) in ARPE-19 cells[1]. |
| References |
| Molecular Formula | C21H16N2O4 |
|---|---|
| Molecular Weight | 360.36300 |
| Exact Mass | 360.11100 |
| PSA | 99.26000 |
| LogP | 3.10720 |
